Figure 2.

MnSOD over-expression during adulthood is necessary and sufficient for lifespan extension and does not result in increased oxidative stress. (a-c) Aconitase enzyme activity measured in mU/mg plotted against age for the following lines: control (a), MnSOD(2)22 (b), and MnSOD(2)12 (c). (d-f) The effect of timing of MnSOD induction on lifespan for control (d), MnSOD(2)22 (e) and MnSOD(2)12 (f).