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Classification of CNB domains in the public and GOS data |
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| No. |
Family name |
NR/GOS count |
Taxonomic origin |
PBC consensus motif |
Description |
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| 1 |
PKA-Rsub |
301/0 |
Eukaryote |
GELALIYGTPRAATVVA |
cAMP dependent regulatory subunit that activates PKA |
| 2 |
PKG |
388/9 |
Eukaryote |
GELALLYNDPRTATVIA |
cGMP activated proteins that are typically attached to a kinase domain |
| 3 |
PKG-parasites |
362/11 |
Eukaryote |
GERALLYDEPRSATIKA |
A distinct group of PKGs in parasites that are also attached to kinase domains |
| 4 |
Other_eukaryotic |
940/201 |
Eukaryote |
GELALLYNAPRAATVVA |
CNB domains from metazoans and plants. These are attached to various functional domains such as PKs, PAS domains, PP2C like phosphatases and phospholipases |
| 5 |
Epac |
150/1 |
Eukaryote |
GQLALVNDAPRAATIVL |
cAMP-dependent guanine nucleotide exchange factors. Typically attached to an amino-terminal DEP domain and a carboxy-terminal RasGEF domain |
| 6 |
PDZ-GEF |
125/0 |
Eukaryote |
GVSPTMDKEYMKGVMRT |
A distinct class of Epac's, also called Epac6, which contains a PDZ domain in between the CNB and RasGEF domain. Epac's of this class contain a non-canonical PBC |
| 7 |
K-channel |
86/0 |
Eukaryote |
GEVGVLCYRPQLFTVRT |
Potassium channels specific to plants. Most of them contain an Ankryin repeat carboxy-terminal to the CNB domain |
| 8 |
LR_CC |
148/4 |
Eukaryote |
GEIGVLLDPPRTATVRA |
CNB domains found in metazoans and fungi, usually occur in tandem like the PKA regulatory subunit and contain a carboxy-terminal F-box domain and leucine rich domain |
| 9 |
HCN |
165/5 |
Eukaryote |
GEICLLTRGRRTASVRA |
cGMP-gated cation channels. Mostly present in metazoans |
| 10 |
K_HCN |
185/0 |
Eukaryote |
GENFWLYGTKSNADVRA |
Potassium channels that contain a PAC motif (motif carboxy-terminal of PAS) amino-terminal of the trans-membrane segment. This subfamily also contains a non-canonical PBC |
| 11 |
Channel_Tetrahym. |
218/44 |
Eukaryote |
GEEDFFSGQPRTFTAKC |
Likely HCN channels from the single celled eukaryote Tetrahymena thermophila. This subfamily is quite distinct from the HCN channels in higher eukaryotes |
| 12 |
Channel_protozoa |
587/41 |
Eukaryote |
GEISFFTGLPRTASARS |
Other HCN channels in protozoans |
| 13 |
Bact_Pyrredox |
38/70 |
Prokaryote |
GEMGLISGRRRGATVRA |
Tandem CNB domains that are attached to an amino-terminal pyridine nucleotide-disulphide oxidoreductase domain |
| 14 |
Channel_Bact |
99/79 |
Prokaryote |
GEIALLTGGPRTATVRA |
Bacterial CNBs that are attached to mechanosensitive ion channels |
| 15 |
HisK |
56/11 |
Prokaryote |
GELSLLTGGPRSATVRA |
Bacterial CNBs that contain a HisK like ATPase, carboxy-terminal of the CNB domain |
| 16 |
AAA_Atpase |
65/24 |
Prokaryote |
GEMALLSGQERKASVIA |
A distinct sub-group containing AAA-ATPase domains attached to the CNB domain. Several members of this group contain an ABC-transporter like transmembrane region. The PBC arginine (Arg209) is quite variable within this family |
| 17 |
NtcA |
108/104 |
Prokaryote |
GVLSLLTGSDRFYHAVA |
Nitrogen responsive regulatory protein that contains a DNA binding domain (HTH) carboxy-terminal of the CNB domain |
| 18 |
FixK |
43/0 |
Prokaryote |
G-ASLGGDHLFTAEA |
Involved in nitrogen fixation and contains a HTH motif |
| 19 |
FnR |
176/53 |
Prokaryote |
GEFDAIGSGHHPSFAQA |
Transcriptional regulators that are implicated in oxygen sensing |
| 20 |
ArcR |
29/0 |
Prokaryote |
PYGGLFTDDYYHESATA |
Transcriptional regulator that is implicated in the aerobic arginase reaction. Arginine is used as a source of energy in bacteria |
| 21 |
NnR |
28/0 |
Prokaryote |
GFARALQRGDYPGTATA |
Transcriptional regulators that act on the nir and nor operons to achieve expression under aerobic conditions |
| 22 |
CBS |
173/51 |
Prokaryote |
GERALLAGGPYSLTARA |
This group contains tandem CBS domain located carboxy-terminal of the CNB domain |
| 23 |
Other_bacterial |
1553/1486 |
Prokaryote |
GEMALLDGEPRSATVVA |
Bacterial CNB domains that are attached to various functional domains such as CheY response regulators, Rhodanese homology domain, kinases and DNA binding domains |
| 24 |
HTH_ICLR |
33/14 |
Prokaryote |
GEGAAFSEEPRSTTVVA |
Transcriptional regulator that is implicated in the repression of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium |
| 25 |
HTH_GNTR |
85/52 |
Prokaryote |
GEASLFDGEPRSATVVA |
Transcriptional regulator containing a HTH domain and implicated in the repression of the gluconate operon |
| 26 |
Flp |
19/0 |
Prokaryote |
GEEALFGESNHANYCEA |
Involved in the bacterial oxidative stress response |
| 27 |
HTH_ARSR |
66/15 |
Prokaryote |
GEAALFSNGPYPATAIA |
Functions as a transcriptional repressor of an arsenic resistance operon. Dissociates from DNA in the presence of the metal |
| 28 |
HTH_CRP |
858/347 |
Prokaryote |
GEAALFDGGPRPATAVA |
Transcriptional regulation of the crp operon |
| 29 |
HTH_MARR |
143/20 |
Prokaryote |
GEMALLDGGPRSADAVA |
Repressor of genes that activate the multiple antibiotic resistance and oxidative stress regulons |
| 30 |
HTH_ASNC |
73/24 |
Prokaryote |
GEIALLDGGPRSATATA |
An autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli |
Kannan et al. Genome Biology 2007 8:R264 doi:10.1186/gb-2007-8-12-r264 |
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