Table 1 |
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The 50 most highly expressed genes in vitro |
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| Rv |
Name |
ppm |
Function [40] |
|
|
|
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| 1 |
Rv0009 |
ppiA |
13,634 |
Protein translation and modification |
| 2 |
Rv2527 |
Rv2527 |
10,020 |
Conserved hypotheticals |
| 3 |
Rv3418c |
groES |
8,651 |
Chaperones-heat shock* |
| 4 |
Rv3615c |
Rv3615c |
8,531 |
Conserved hypotheticals* |
| 5 |
Rv0440 |
groEL2 |
8,300 |
Chaperones-heat shock* |
| 6 |
Rv3258c |
Rv3258c |
5,430 |
Unknown* |
| 7 |
Rv3616c |
Rv3616c |
5,370 |
Conserved hypotheticals* |
| 8 |
Rv3477 |
PE31 |
5,138 |
PE subfamily |
| 9 |
Rv2244 |
acpM |
4,935 |
Synthesis of fatty and mycolic acids* |
| 10 |
Rv0060 |
Rv0060 |
4,616 |
Unknown* |
| 11 |
Rv3874 |
Rv3874 |
4,490 |
Conserved hypotheticals |
| 12 |
Rv3875 |
esat6 |
4,115 |
SP, L, P and A† |
| 13 |
Rv3648c |
cspA |
4,101 |
Adaptations and atypical conditions* |
| 14 |
Rv3053c |
nrdH |
3,934 |
2'-Deoxyribonucleotide metabolism |
| 15 |
Rv3614c |
Rv3614c |
3,748 |
Conserved hypotheticals* |
| 16 |
Rv1078 |
pra |
3,582 |
Conserved hypotheticals |
| 17 |
Rv2780 |
ald |
3,577 |
Amino acids and amines |
| 18 |
Rv1388 |
mIHF |
3,499 |
Nucleoproteins* |
| 19 |
Rv0003 |
recF |
3,371 |
DNA R, R R and R‡ |
| 20 |
Rv3786c |
Rv3786c |
3,164 |
Unknown |
| 21 |
Rv1641 |
infC |
2,993 |
Protein translation and modification* |
| 22 |
Rv3269 |
Rv3269 |
2,778 |
Chaperones-heat shock |
| 23 |
Rv1398c |
Rv1398c |
2,777 |
Conserved hypotheticals |
| 24 |
Rv3407 |
Rv3407 |
2,732 |
Conserved hypotheticals |
| 25 |
Rv2245 |
kasA |
2,693 |
Synthesis of fatty and mycolic acids* |
| 26 |
Rv0685 |
tuf |
2,688 |
Protein translation and modification* |
| 27 |
Rv2145c |
wag31 |
2,652 |
SP, L, P and A*† |
| 28 |
Rv1306 |
atpF |
2,620 |
ATP-proton motive force* |
| 29 |
Rv0005 |
gyrB |
2,466 |
DNA R, R R and R*‡ |
| 30 |
Rv1305 |
atpE |
2,455 |
ATP-proton motive force* |
| 31 |
Rv0016c |
pbpA |
2,423 |
Murein sacculus and peptidoglycan |
| 32 |
Rv1622c |
cydB |
2,418 |
Electron transport* |
| 33 |
Rv3219 |
whiB1 |
2,373 |
Repressors-activators |
| 34 |
Rv3583c |
Rv3583c |
2,345 |
Repressors-activators |
| 35 |
Rv1980c |
mpt64 |
2,254 |
SP, L, P and A† |
| 36 |
Rv1072 |
Rv1072 |
2,205 |
Other membrane proteins |
| 37 |
Rv2457c |
clpX |
2,200 |
Proteins, peptides and glycopeptides* |
| 38 |
Rv1958c |
Rv1958c |
2,195 |
Unknown |
| 39 |
Rv3763 |
lpqH |
2,180 |
Lipoproteins (lppA-lpr0) |
| 40 |
Rv1872c |
lldD2 |
2,149 |
Aerobic respiration |
| 41 |
Rv3461c |
rpmJ |
2,133 |
Ribosomal protein synthesis* |
| 42 |
Rv1361c |
PPE19 |
2,127 |
PPE family |
| 43 |
Rv0097 |
Rv0097 |
2,123 |
Conserved hypotheticals |
| 44 |
Rv1971 |
Rv1971 |
2,034 |
Virulence |
| 45 |
Rv3051c |
nrdE |
1,984 |
2'-Deoxyribonucleotide metabolism* |
| 46 |
Rv2346c |
Rv2346c |
1,937 |
Conserved hypotheticals |
| 47 |
Rv3679 |
Rv3679 |
1,931 |
Anions* |
| 48 |
Rv1298 |
rpmE |
1,883 |
Ribosomal protein synthesis* |
| 49 |
Rv0108c |
Rv0108c |
1,837 |
Unknown |
| 50 |
Rv2193 |
ctaE |
1,793 |
Aerobic respiration* |
|
|
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|
*Essential genes (TraSH) [26,27]. †Surface polysaccharides, lipopolysaccharides, proteins and antigens. ‡DNA replication, repair, recombination and restriction-modification. |
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|
Sidders et al. Genome Biology 2007 8:R265 doi:10.1186/gb-2007-8-12-r265 |
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