Table 1

The 50 most highly expressed genes in vitro

Rv

Name

ppm

Function [40]


1

Rv0009

ppiA

13,634

Protein translation and modification

2

Rv2527

Rv2527

10,020

Conserved hypotheticals

3

Rv3418c

groES

8,651

Chaperones-heat shock*

4

Rv3615c

Rv3615c

8,531

Conserved hypotheticals*

5

Rv0440

groEL2

8,300

Chaperones-heat shock*

6

Rv3258c

Rv3258c

5,430

Unknown*

7

Rv3616c

Rv3616c

5,370

Conserved hypotheticals*

8

Rv3477

PE31

5,138

PE subfamily

9

Rv2244

acpM

4,935

Synthesis of fatty and mycolic acids*

10

Rv0060

Rv0060

4,616

Unknown*

11

Rv3874

Rv3874

4,490

Conserved hypotheticals

12

Rv3875

esat6

4,115

SP, L, P and A

13

Rv3648c

cspA

4,101

Adaptations and atypical conditions*

14

Rv3053c

nrdH

3,934

2'-Deoxyribonucleotide metabolism

15

Rv3614c

Rv3614c

3,748

Conserved hypotheticals*

16

Rv1078

pra

3,582

Conserved hypotheticals

17

Rv2780

ald

3,577

Amino acids and amines

18

Rv1388

mIHF

3,499

Nucleoproteins*

19

Rv0003

recF

3,371

DNA R, R R and R

20

Rv3786c

Rv3786c

3,164

Unknown

21

Rv1641

infC

2,993

Protein translation and modification*

22

Rv3269

Rv3269

2,778

Chaperones-heat shock

23

Rv1398c

Rv1398c

2,777

Conserved hypotheticals

24

Rv3407

Rv3407

2,732

Conserved hypotheticals

25

Rv2245

kasA

2,693

Synthesis of fatty and mycolic acids*

26

Rv0685

tuf

2,688

Protein translation and modification*

27

Rv2145c

wag31

2,652

SP, L, P and A*

28

Rv1306

atpF

2,620

ATP-proton motive force*

29

Rv0005

gyrB

2,466

DNA R, R R and R*

30

Rv1305

atpE

2,455

ATP-proton motive force*

31

Rv0016c

pbpA

2,423

Murein sacculus and peptidoglycan

32

Rv1622c

cydB

2,418

Electron transport*

33

Rv3219

whiB1

2,373

Repressors-activators

34

Rv3583c

Rv3583c

2,345

Repressors-activators

35

Rv1980c

mpt64

2,254

SP, L, P and A

36

Rv1072

Rv1072

2,205

Other membrane proteins

37

Rv2457c

clpX

2,200

Proteins, peptides and glycopeptides*

38

Rv1958c

Rv1958c

2,195

Unknown

39

Rv3763

lpqH

2,180

Lipoproteins (lppA-lpr0)

40

Rv1872c

lldD2

2,149

Aerobic respiration

41

Rv3461c

rpmJ

2,133

Ribosomal protein synthesis*

42

Rv1361c

PPE19

2,127

PPE family

43

Rv0097

Rv0097

2,123

Conserved hypotheticals

44

Rv1971

Rv1971

2,034

Virulence

45

Rv3051c

nrdE

1,984

2'-Deoxyribonucleotide metabolism*

46

Rv2346c

Rv2346c

1,937

Conserved hypotheticals

47

Rv3679

Rv3679

1,931

Anions*

48

Rv1298

rpmE

1,883

Ribosomal protein synthesis*

49

Rv0108c

Rv0108c

1,837

Unknown

50

Rv2193

ctaE

1,793

Aerobic respiration*


*Essential genes (TraSH) [26,27]. Surface polysaccharides, lipopolysaccharides, proteins and antigens. DNA replication, repair, recombination and restriction-modification.

Sidders et al. Genome Biology 2007 8:R265   doi:10.1186/gb-2007-8-12-r265

Open Data