Table 2

The 133 genes of the 'abundant invariome'

Rv

Name

Avg ppm

Stdev

Essential


1

Rv3874

lhp

5,414

3,950

-

2

Rv3418c

groES

5,189

2,593

In vitro

3

Rv0440

groEL2

4,438

2,385

In vitro

4

Rv3615c

Rv3615c

3,887

2,539

In vivo

5

Rv0009

ppiA

3,460

4,587

-

6

Rv3616c

Rv3616c

2,619

1,457

In vivo

7

Rv3477

PE31

2,537

1,553

-

8

Rv2244

acpM

2,475

1,304

In vitro

9

Rv3875

esat6

2,472

1,229

-

10

Rv1398c

Rv1398c

2,449

1,311

-

11

Rv3648c

cspA

2,372

1,149

In vitro

12

Rv2245

kasA

2,236

481

In vitro

13

Rv3614c

Rv3614c

2,232

847

In vivo

14

Rv1307

atpH

2,151

1,195

In vitro

15

Rv0667

rpoB

2,105

563

In vitro

16

Rv1388

mihF

2,103

1,013

In vitro

17

Rv0685

tuf

2,100

792

In vitro

18

Rv3583c

Rv3583c

2,096

2,027

-

19

Rv3053c

nrdH

1,930

1,339

-

20

Rv1133c

metE

1,915

323

In vitro

21

Rv1072

Rv1072

1,897

560

-

22

Rv1872c

lldD2

1,817

574

-

23

Rv3461c

rpmJ

1,814

795

In vitro

24

Rv2457c

clpX

1,790

343

In vitro

25

Rv0700

rpsJ

1,693

1,148

In vitro

26

Rv1078

pra

1,643

971

-

27

Rv1298

rpmE

1,529

543

In vitro

28

Rv2840c

Rv2840c

1,495

566

-

29

Rv1630

rpsA

1,491

439

In vitro

30

Rv0046c

ino1

1,488

620

-

31

Rv1886c

fbpB

1,464

1,168

-

32

Rv2196

qcrB

1,455

472

In vitro

33

Rv3443c

rplM

1,447

300

In vitro

34

Rv0701

rplC

1,421

880

In vitro

35

Rv0682

rpsL

1,419

576

In vitro

36

Rv3219

whiB1

1,384

795

-

37

Rv0702

rplD

1,364

619

In vitro

38

Rv0289

Rv0289

1,351

845

In vitro

39

Rv2200c

ctaC

1,332

1,406

In vitro

40

Rv1980c

mpt64

1,316

629

-

41

Rv1306

atpF

1,246

695

In vitro

42

Rv2193

ctaE

1,217

334

In vitro

43

Rv1310

atpD

1,184

412

In vitro

44

Rv1174c

Rv1174c

1,165

424

-

45

Rv1308

atpA

1,148

349

In vitro

46

Rv3051c

nrdE

1,123

578

In vitro

47

Rv1305

atpE

1,086

696

In vitro

48

Rv0683

rpsG

1,080

541

In vitro

49

Rv1297

rho

1,074

281

In vitro

50

Rv2461c

clpP1

1,028

346

-

51

Rv0655

mkl

1,024

385

In vivo

52

Rv3052c

nrdI

1,018

551

-

53

Rv3801c

fadD32

1,015

209

In vitro

54

Rv0005

gyrB

1,011

684

In vitro

55

Rv0704

rplB

1,011

528

In vitro

56

Rv3412

Rv3412

1,002

141

-

57

Rv0250c

Rv0250c

995

439

-

58

Rv2460c

clpP2

991

393

In vitro

59

Rv2204c

Rv2204c

963

277

-

60

Rv3478

PPE60

957

360

-

61

Rv0703

rplW

956

556

In vitro

62

Rv2094c

tatA

949

241

-

63

Rv1303

Rv1303

939

637

In vitro

64

Rv3456c

rplQ

937

297

-

65

Rv0719

rplF

925

406

In vitro

66

Rv0684

fusA1

923

367

In vitro

67

Rv2347c

Rv2347c

920

447

-

68

Rv0715

rplX

906

342

In vitro

69

Rv1197

Rv1197

906

440

-

70

Rv1479

moxR1

898

162

In vitro

71

Rv0718

rpsH

886

243

In vitro

72

Rv3460c

rpsM

882

373

-

73

Rv2194

qcrC

870

194

In vitro

74

Rv2195

qcrA

868

189

In vitro

75

Rv0860

fadB

863

420

-

76

Rv1309

atpG

861

401

In vitro

77

Rv0243

fadA2

859

231

-

78

Rv3248c

sahH

850

243

In vitro

79

Rv0020c

TB39.8

850

224

-

80

Rv3584

lpqE

845

246

-

81

Rv1793

Rv1793

836

309

-

82

Rv3620c

Rv3620c

827

375

-

83

Rv1410c

Rv1410c

815

188

In vivo

84

Rv3459c

rpsK

809

206

In vitro

85

Rv0483

lprQ

805

341

-

86

Rv3043c

ctaD

803

221

In vitro

87

Rv3029c

fixA

801

232

In vitro

88

Rv2868c

gcpE

799

384

-

89

Rv1304

atpB

796

203

In vivo

90

Rv1642

rpmI

784

388

-

91

Rv1794

Rv1794

781

254

-

92

Rv0288

cfp7

781

286

-

93

Rv3810

pirG

778

131

In vivo

94

Rv1543

Rv1543

770

222

-

95

Rv3680

Rv3680

765

294

-

96

Rv3457c

rpoA

760

293

In vitro

97

Rv3045

adhC

756

272

-

98

Rv1792

Rv1792

753

326

-

99

Rv2969c

Rv2969c

738

141

In vitro

100

Rv1177

fdxC

736

303

In vitro

101

Rv3867

Rv3867

735

200

-

102

Rv1038c

Rv1038c

724

391

-

103

Rv2890c

rpsB

715

120

In vitro

104

Rv3224

Rv3224

709

303

-

105

Rv3458c

rpsD

707

208

In vitro

106

Rv2785c

rpsO

690

316

-

107

Rv2986c

hupB

687

255

In vitro

108

Rv0174

mce1F

683

211

-

109

Rv3211

rhlE

676

251

-

110

Rv1436

gap

673

234

In vitro

111

Rv0351

grpE

672

282

In vitro

112

Rv2764c

thyA

667

239

-

113

Rv1311

atpC

660

160

In vitro

114

Rv0432

sodC

657

177

-

115

Rv1791

PE19

655

232

-

116

Rv0932c

pstS2

652

249

-

117

Rv2971

Rv2971

645

188

In vitro

118

Rv1300

hemK

644

220

In vitro

119

Rv2703

sigA

643

114

In vitro

120

Rv2203

Rv2203

633

196

-

121

Rv0423c

thiC

614

149

In vitro

122

Rv2587c

secD

602

267

-

123

Rv1887

Rv1887

601

148

-

124

Rv0313

Rv0313

588

136

-

125

Rv0502

Rv0502

559

147

-

126

Rv3841

bfrB

542

107

-

127

Rv2115c

Rv2115c

529

106

-

128

Rv3587c

Rv3587c

526

68

-

129

Rv2110c

prcB

516

151

In vitro

130

Rv1987

Rv1987

495

136

-

131

Rv2454c

Rv2454c

489

55

-

132

Rv0125

pepA

483

80

-

133

Rv1324

Rv1324

474

152

-


Using our measure of absolute mRNA levels, we have been able to identify the genes whose level of expression remains consistently high across a variety of growth conditions. These genes remain amongst the top 15% most highly expressed genes across all of the conditions tested. We have termed the genes whose level of expression does not vary greatly as invariant, and, therefore, the subset of genes included in this table is dubbed the 'abundant invariome'.

Sidders et al. Genome Biology 2007 8:R265   doi:10.1186/gb-2007-8-12-r265

Open Data