Genome Biology

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Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity

Sara Holland, Emma Lodwig, Theodora Sideri, Tom Reader, Ian Clarke, Konstantinos Gkargkas, David C Hoyle, Daniela Delneri, Stephen G Oliver and Simon V Avery*

Genome Biology 2007, 8:R268 doi:10.1186/gb-2007-8-12-r268

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Research article   Open Access

Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast.

Karin Lanthaler, Elizabeth Bilsland, Paul D Dobson, Harry J Moss, Pinar Pir, Douglas B Kell, Stephen G Oliver BMC Biology 2011, 9:70 (24 October 2011)

Research   Open Access

Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection

Nicoletta Bivi, Milena Romanello, Richard Harrison, Ian Clarke, David C Hoyle, Luigi Moro, Fulvia Ortolani, Antonella Bonetti, Franco Quadrifoglio, Gianluca Tell, Daniela Delneri Genome Biology 2009, 10:R93 (10 September 2009)

Growth competition assays using barcoded yeast deletion-mutants reveal the molecular targets of nitrogen containing bisphosphonates used for the treatment of bone cancers and osteoporosis.

Research   Open Access

Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast

Roberta Ruotolo, Gessica Marchini, Simone Ottonello Genome Biology 2008, 9:R67 (7 April 2008)

Genomic phenotyping was used to assess the role of all non-essential S. cerevisiae proteins in modulating cell viability after exposure to cadmium, nickel and other metals.