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Decoding dosage compensation

Xinxian Deng and Christine M Disteche*

Author Affiliations

Department of Pathology, University of Washington, Seattle, WA 98195, USA

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Genome Biology 2007, 8:204  doi:10.1186/gb-2007-8-2-204

Published: 26 February 2007

Abstract

How the mechanisms of dosage compensation distinguish the sex chromosomes from the autosomes has been something of a mystery. A recent study in Caenorhabditis elegans has identified clusters of two common DNA motifs as a cis-acting code for the recruitment of the DCC, the protein complex that mediates dosage compensation.