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Correspondence

Systematic overestimation of gene gain through false diagnosis of gene absence

Olga Zhaxybayeva*, Camilla L Nesbø and W Ford Doolittle

Author Affiliations

Department of Biochemistry and Molecular Biology, Dalhousie University, 5850 College Street, Halifax, NS, B3H 1X5 Canada

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Genome Biology 2007, 8:402  doi:10.1186/gb-2007-8-2-402

Published: 26 February 2007

Abstract

The usual BLAST-based methods for assessing gene presence and absence lead to systematic overestimation of within-species gene gain by lateral transfer.