Research
Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans
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* Corresponding author: Tanya Vavouri tv1@sanger.ac.uk
- † Equal contributors
1 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
2 School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, UK
3 MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR, UK
4 Department of Statistics, University of Leeds, Leeds LS2 9JT, UK
5 EMBL/CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), UPF, C/Dr. Aiguader 88, Barcelona 08003, Spain
Genome Biology 2007, 8:R15 doi:10.1186/gb-2007-8-2-r15
Published: 2 February 2007Additional files
Additional data file 1:
Distribution of wCNEs along each chromosome.
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Additional data file 2:
Distribution of distances between CNEs in both the C. elegans and the H. sapiens genomes and for randomized CNE locations.
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Additional data file 3:
Distribution of distances between intergenic wCNEs and their nearest genes.
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Additional data file 4:
Top-level InterPro protein domains significantly enriched in CNE-associated genes compared to the rest of the genes in the (a) H. sapiens and (b) C. elegans genomes.
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Additional data file 5:
Enrichment for transcription factors among wCNE-associated genes, using two different collections of predicted transcription factors from the C. elegans genome.
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Additional data file 6:
wCNEs overlapping known cis-regulatory elements.
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Additional data file 7:
Annotation features from WormBase that were used to annotate wCNEs.
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Additional data file 9:
Coordinates of the wCNEs in the C. elegans genome, their nearest genes and their human orthologs.
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Additional data file 10:
Coordinates of the human CNEs from Woolfe et al. [4] with their nearest genes assigned using the same method as for the wCNEs.
Format: XLS Size: 104KB Download file
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