Figure 3.

CNEs are associated with genes involved in transcription regulation and development in both H. sapiens and C. elegans. The log odds ratios and the 95% confidence intervals are shown for all GOslim terms that appear in the annotation of genes spatially associated with CNEs significantly more often than in the rest of the genome for H. sapiens (black) and C. elegans (red). GOslim terms marked with three asterisks are significantly enriched in both H. sapiens and C. elegans CNE genes; those marked with two asterisks are significantly enriched only in C. elegans; and the term with one asterisk is significantly enriched only in H. sapiens. The domains are ordered according to their p value in H. sapiens (lowest p value in H. sapiens at the top). All terms related to transcription factor activity and development (that is, 'trans-dev' genes [4]) show a strong bias in the annotation of genes near CNEs in both genomes. In the C. elegans gene set, there is also a trend for genes to be involved in signal transduction and ion binding. The GO terms shown in this figure constitute all GOslim terms (excluding the term 'biological-process') with a positive log odds ratio and p value ≤ 7.19 × 10-3 (5% false discovery rate cut-off) in either H. sapiens or C. elegans.