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Open Access Method

Clustering of phosphorylation site recognition motifs can be exploited to predict the targets of cyclin-dependent kinase

Alan M Moses*, Jean-Karim Hériché and Richard Durbin

Author Affiliations

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1HH, UK

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Genome Biology 2007, 8:R23  doi:10.1186/gb-2007-8-2-r23

Published: 22 February 2007

Abstract

Protein kinases are critical to cellular signalling and post-translational gene regulation, but their biological substrates are difficult to identify. We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. Based on this, we introduce a new computational strategy to predict the targets of CDKs and use it to identify new biologically interesting candidates. Our data suggest that regulatory modules may exist in protein sequence as clusters of short sequence motifs.