Research
DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies
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* Corresponding author: Carrolee Barlow cbarlow@braincellsinc.com
- † Equal contributors
1 The Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
2 National Public Health Institute, Department of Molecular Medicine, Haartmaninkatu 8, 00290 Helsinki, Finland
3 INSERM U513, Neurobiology and Psychiatry, Faculté de Médecine, 8 rue du Général Sarrail, Créteil 94010 cedex, France
4 Biomedical Sciences Graduate Program, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
5 Polymorphism Research Laboratory, Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
6 Neurome Inc., 11149 North Torrey Pines Road, La Jolla, CA 92037, USA
7 Rosetta Inpharmatics Inc., 401 Terry Avenue North, Seattle, WA 98109, USA
8 Amicus Therapeutics, 6 Ceder Brook Drive, Cranbury, NJ 08512, USA
9 BrainCells Inc., 10835 Road to the Cure, San Diego, CA 92121, USA
Genome Biology 2007, 8:R25 doi:10.1186/gb-2007-8-2-r25
Published: 26 February 2007Additional files
Additional data file 1:
This file contains F statistics and P values for brain region, strain, and interaction effects from the multiple regression model and two-way ANOVA; only genes that scored as 'Present' in at least one file are included.
Format: TXT Size: 3.1MB Download file
Additional data file 2:
This table shows the number of strain-specific and brain region-specific probe sets with genetic cis-associations after removing probe sets with putative polymorphisms using a detection algorithm.
Format: PDF Size: 23KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional data file 3:
This file includes detailed methods used in the microarray data pre-processing.
Format: PDF Size: 30KB Download file
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Additional data file 4:
This file contains the SNP marker positions and genotypes.
Format: PDF Size: 324KB Download file
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Additional data file 5:
This file contains the genomic start and end positions of genes used in the eQTL analysis.
Format: PDF Size: 1.1MB Download file
This file can be viewed with: Adobe Acrobat Reader