Genome Biology

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A network perspective on the evolution of metabolism by gene duplication

Juan J Díaz-Mejía, Ernesto Pérez-Rueda and Lorenzo Segovia*

Genome Biology 2007, 8:R26 doi:10.1186/gb-2007-8-2-r26

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Research article   Open Access

Horizontal and vertical growth of S. cerevisiae metabolic network

Luigi Grassi, Anna Tramontano BMC Evolutionary Biology 2011, 11:301 (14 October 2011)

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Difference in the distribution pattern of substrate enzymes in the metabolic network of Escherichia coli, according to chaperonin requirement

Kazuhiro Takemoto, Tatsuya Niwa, Hideki Taguchi BMC Systems Biology 2011, 5:98 (24 June 2011)

Methodology article   Open Access Highly Accessed

Metabolic pathway alignment between species using a comprehensive and flexible similarity measure

Yunlei Li, Dick de Ridder, Marco JL de Groot, Marcel JT Reinders BMC Systems Biology 2008, 2:111 (24 December 2008)

Both conserved and unique pathways can be identified by employing a new framework, Metabolic Pathway Alignment and Scoring (M-PAS), based on comparative analysis of metabolic networks between species.

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Network-based approaches for linking metabolism with environment

Sarath Janga, M Madan Babu Genome Biology 2008, 9:239 (24 November 2008)

Genome-wide metabolic maps allow the development of network-based computational approaches for linking an organism with its biochemical habitat.

Research article   Open Access

Origin of structural difference in metabolic networks with respect to temperature

Kazuhiro Takemoto, Tatsuya Akutsu BMC Systems Biology 2008, 2:82 (22 September 2008)

Research   Open Access Highly Accessed

The hidden universal distribution of amino acid biosynthetic networks: a genomic perspective on their origins and evolution

Georgina Hernández-Montes, J Javier Díaz-Mejía, Ernesto Pérez-Rueda, Lorenzo Segovia Genome Biology 2008, 9:R95 (9 June 2008)

A core of widely distributed network branches biosynthesizing at least 16 out of the 20 standard amino acids is predicted using comparative genomics.

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Correlation between structure and temperature in prokaryotic metabolic networks

Kazuhiro Takemoto, Jose C Nacher, Tatsuya Akutsu BMC Bioinformatics 2007, 8:303 (21 August 2007)