Research
A network perspective on the evolution of metabolism by gene duplication
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* Corresponding author: Lorenzo Segovia lorenzo@ibt.unam.mx
Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México. Av. Universidad 2001, Col. Chamilpa, Cuernavaca, Morelos, CP 62210 México
Genome Biology 2007, 8:R26 doi:10.1186/gb-2007-8-2-r26
Published: 27 February 2007Additional files
Additional data file 1:
Reconstructed metabolic networks from various databases (EcoKegg, EcoCyc, RefKegg and MetaCyc), eliminating hubs gradually in each database.
Format: TXT Size: 6.8MB Download file
Additional data file 2:
Amino-acid sequences of the enzymes analyzed in this work.
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Additional data file 3:
Domains detected in the amino-acid sequences of the enzymes analyzed, grouped by EC numbers.
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Additional data file 4:
Results of retention of duplicates in various databases, gradually removing hubs.
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Additional data file 5:
Controls for the multidomain enzymes, the criteria of chemical similarity, and the method used to detect duplicates.
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