Table 1

Exonic regulatory sequences predicted to be changed following editing in the five exonic sites

Site e1*

Site e2*

Site e3*

Site e4*

Site e5*

SF2/ASF^†

CACACCT (3.2/3.6)

CTCAGGA (4.8/NA)

SC35^†

AATCACAG (NA/4)

AATCACAG (NA/2.6)

SRp40^†

GCACACC (2.6/NA)

CTACTCA (NA/5.1)

ACTCAGG (4.2/NA)

SRp55^†

TGCACA (NA/3.1)

Ast^‡

AGTGCA^§

TCAGGA

Burge^¶¥

TGGTGG

GGGAGG

GGTAGT

TCAGGA

hnRNP F

GGGA

The sequence of the exonic splicing regulatory sequence is shown. The edited 'A' nucleotide is in bold (unless otherwise indicated). The numbers in parentheses indicate the binding score before/after editing; NA indicates no available score. *Edited sites: E1, position 19 in the Alu-exon; E2, position 24; E3, position 32; E4, position 33; E5, position 46. ^†Predicted by ESEfinder [31]. ^‡Predicted by Goren et al. [28]. ^§This unedited ESR overlaps with both E1 and E2 sites. ^¶Predicted by RESCU-ESE [30]. ^¥Sites E1 and E5 created two different hexamers for the edited and unedited position, according to RESCU-ESE [30].

Lev-Maor et al. Genome Biology 2007 8:R29   doi:10.1186/gb-2007-8-2-r29