Figure 1.

Multiple alignment of RBR domain segments. The figure includes the sequences of 64 representative RBR segments. This alignment is part of the grand alignment used to create the phylogenetic tree in Figure 2. The sequence identifier gives the subfamily code (first letter) followed by the taxon and the accession number in GenBank. The loop segments between the three ring-like domains are indicated by 'XX'. The gray bars at the bottom represent the degree of amino acid type conservation of alignment positions. The alignment was primarily generated with CLUSTALX [70] and edited manually. Taxon abbreviations: Am, Apis mellifera; At, Arabidopsis thaliana; Ce, Caenorhabditis elegans; Dd, Dictyostelium discoideum; Dm, Drosophila melanogaster; Dr, Danio rerio; Gz, Gibberella zeae; Hs, Homo sapiens; Nc, Neurospora crassa; Sp, Schizosaccharomyces pombe.