Genome Biology

official impact factor 6.89

Open Access Research

Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease

Erin L Heinzen1, Woohyun Yoon1, Michael E Weale1, Arjune Sen2, Nicholas W Wood3, James R Burke4, Kathleen A Welsh-Bohmer4, Christine M Hulette4, Sanjay M Sisodiya2 and David B Goldstein1*

Author Affiliations

1 Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, Durham, NC 27710, USA

2 Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London WC1N 3BG, UK

3 Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK

4 Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC 27710, USA

For all author emails, please log on.

Genome Biology 2007, 8:R32 doi:10.1186/gb-2007-8-3-r32

Published: 7 March 2007

Additional files

Additional data file 1:

Taqman® assays and custom-designed primer/probe sequences used in rtPCR studies to confirm the presence of the splice variants.

Format: DOC Size: 48KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional data file 2:

Additional methods, discussion and figures regarding the assessment of cellular composition of the brain tissue samples used in these studies.

Format: DOC Size: 40KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data