Figure 12.

Expression signatures of wholly intronic RNAs relative to their 3' protein-coding exons. Cross-referencing of the tissue signatures shown in Figure 10 identified subsets of TIN RNAs that have correlated patterns of expression relative to the 3' protein-coding exon signature from the corresponding genomic loci: (a) 38 pairs were identified in which the 3' exon of the protein-coding transcript (right panel) follows a similar expression pattern to that of the antisense TIN RNA (left panel); (b) 16 pairs were identified in which the 3' exon of the protein-coding transcript (right panel) follows a pattern of tissue expression inverted in relation to that of the antisense TIN RNA (left panel); (c) 64 pairs were identified in which the 3' exon of the protein-coding transcript (right panel) follows a similar expression pattern as that of the sense TIN RNA (left panel); (d) 22 pairs were identified where the 3' exon of the protein-coding transcript (right panel) follows a pattern of tissue expression inverted in relation to that of the sense TIN RNA (left panel). For each line in each panel, expression intensities among the three tissues were normalized within each type of probe and colored as a function of the number of standard deviations from the mean value.