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Highly Accessed Review

Searching genomes for ribozymes and riboswitches

Christian Hammann1 and Eric Westhof2*

Author Affiliations

1 Research Group Molecular Interactions, Department of Genetics, FB 18 Naturwissenschaften, Universität Kassel, D-34132 Kassel, Germany

2 Architecture et Réactivité de l'ARN, Université Louis Pasteur de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, CNRS, rue René Descartes, F-67084 Strasbourg Cedex, France

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Genome Biology 2007, 8:210  doi:10.1186/gb-2007-8-4-210

Published: 30 April 2007

Abstract

New regulatory RNAs with complex structures have recently been discovered, among them the first catalytic riboswitch, a gene-regulatory RNA sequence with catalytic activity. Here we discuss some of the experimental approaches and theoretical difficulties attached to the identification of new ribozymes in genomes.