Genome Biology
Volume 8
Issue 4 |
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 ReviewSearching genomes for ribozymes and riboswitchesChristian Hammann1 and Eric Westhof2  1Research Group Molecular Interactions, Department of Genetics, FB 18 Naturwissenschaften, Universität Kassel, D-34132 Kassel, Germany 2Architecture et Réactivité de l'ARN, Université Louis Pasteur de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, CNRS, rue René Descartes, F-67084 Strasbourg Cedex, France  author email corresponding author email
Genome Biology 2007,
8:210doi:10.1186/gb-2007-8-4-210
Subject areas: Biochemistry and structural biology, Genome studies, Molecular biology Abstract
New regulatory RNAs with complex structures have recently been discovered, among them the first catalytic riboswitch, a gene-regulatory RNA sequence with catalytic activity. Here we discuss some of the experimental approaches and theoretical difficulties attached to the identification of new ribozymes in genomes. | 
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