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Data sets investigated in this study |
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| Pairwise interactions (%) |
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|
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| Dataset |
PPIs/Complexes |
No. of proteins |
HD |
PD |
F(HD) |
F(PD) |
F(HI) |
F(PI) |
Description |
|
|
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| Pairwise interactions |
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|
|
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| Yeast [36] |
1,011 |
753 |
1.9 |
13.4 |
Manual curation of small scale data (does not include yeast two hybrid data) |
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| Yeast-large [37] |
15,393 |
4,741 |
1.8 |
6.2 |
Compilation of small- and large-scale data |
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| Worm [39] |
2,422 |
1,726 |
1.6 |
3.3 |
High-throughput (yeast two-hybrid) |
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| Fly [38] |
3,384 |
2,877 |
2.9 |
9.1 |
High-throughput (yeast two-hybrid) |
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| Complexes |
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| MIPS [36] |
216 |
1,185 |
32 |
27 |
Manual curation |
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| TAP [40] |
589 |
1,474 |
31 |
30 |
High-throughput tagging and mass spectometry |
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| HMS-PCI [41] |
741 |
1,758 |
33 |
27 |
High-throughput tagging and mass spectometry |
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| PQS [29] |
2509 |
3,124 |
85 |
11 |
Three-dimensional structures of protein complexes |
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|
PPIs/Complexes are the number of protein-protein interactions and protein complexes (for complexes) in the data sets, respectively. HD, homodimers; PD, dimers of paralogous proteins; F(HD) and F(PD) represent the frequency at which the complexes contain homodimers or dimers of paralogous proteins in any of the two S. cerevisiae protein interaction datasets. These numbers were obtained by computationally superimposing the PINs onto the complex data and are significantly higher than expected by chance at p < 10-4 in all cases. F(HI) and F(PI) are the frequency of complexes with homomeric or paralogous interactions, respectively. | |||||||||
Pereira-Leal et al. Genome Biology 2007 8:R51 doi:10.1186/gb-2007-8-4-r51 |
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