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Evolutionary origin of dimers of paralogues |
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| P(HD) |
P(PD) |
P(HD|PD) |
P(PD|HD) |
|
|
|
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| Yeast |
0.034 ± 0.006 |
0.134 ± 0.011 |
0.043 ± 0.006 |
0.17 ± 0.012 |
| Yeast-large |
0.027 ± 0.001 |
0.062 ± 0.002 |
0.203 ± 0.003 |
0.466 ± 0.004 |
| Fly |
0.047 ± 0.004 |
0.091 ± 0.006 |
0.082 ± 0.006 |
0.257 ± 0.008 |
| Worm |
0.031 ± 0.003 |
0.033 ± 0.003 |
0.355 ± 0.008 |
0.379 ± 0.008 |
|
Dimers of paralogues are frequently also homodimers. HD, homodimer; PD, dimer of paralogues. P(HD|PD) should be read as the conditional probability of a polypeptide forming a homodimer given that it also participates in forming a dimer of paralogues. The standard deviations for each probability are calculated from √(p(1 - p)/n) where p is the estimated probability and n the number of observations. The enrichment observed with the conditional probabilities is significant for all interaction datasets except the small yeast network. | ||||
Pereira-Leal et al. Genome Biology 2007 8:R51 doi:10.1186/gb-2007-8-4-r51 |
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