Figure 2.

Genomic environment around Fugu co-orthologs in comparison to the human ortholog. Diagrammatic representation of the genomic environment around Fugu co-orthologs and human orthologs of: (a) BCL11A, (b) EBF1, (c) FIGN, (d) PAX2, (e) SOX1, (f) UNC4.1 and (g) ZNF503. For each gene, the top two lines represent the genic environment around each of the Fugu co-orthologs whilst the third line represents the genic environment around the human ortholog. Regions are not drawn to scale and are representative only. Human chromosome locations and Fugu scaffold IDs are stated to the left of each graphic. Fugu scaffold IDs can be cross-referenced for their exact location through Table 1. All annotation was retrieved from Ensembl Fugu (v36.4) and Human (v.36.35i). Only genes that are conserved in both Fugu and human are shown. Reference trans-dev genes are colored in red and are always orientated in 5'→3' orientation. Surrounding genes in Fugu are marked in blue and in human in green. The names of neighboring Fugu homologs that share conserved synteny with human (but not necessarily the same relative order or orientation) are highlighted in an orange box. Genes orientated in the same direction as the reference trans-dev gene are located above the line and those orientated in the opposite direction are below the line. Yellow triangles represent the positions of the furthest CNEs upstream and downstream in each genomic sequence and delineate the region in which CNEs were identified.