Figure 3.

Comparison of adenovirus-induced changes in gene expression in HeLa cells and HFFs. The genes reported to exhibit changes in expression at (a) 6 hours or (b) 10 and 21 hours after infection of HeLa cells by adenovirus type 2 (Ad2) [54,55] were isolated from our dataset and clustered on the basis of their responses to infection of human foreskin fibroblasts (HFFs). The changes observed in HeLa cells are summarized in the columns labeled Ad2, in which yellow and blue represent increased and decreased expression respectively. In panel b, the HeLa response is based on the average of the two time points. Ramps above panels indicate increases in time after infection.