Table 2 |
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Ligand-binding specificities of human integrins |
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Integrins |
Ligands |
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α1β1 |
Laminin, collagen |
|
α2β1 |
Laminin, collagen, thrombospondin, E-cadherin, tenascin |
|
α3β1 |
Laminin, thrombospondin, uPAR |
|
α4β1 |
Thrombospondin, MAdCAM-1, VCAM-1, fibronectin, osteopontin, ADAM, ICAM-4 |
|
α5β1 |
Fibronectin, osteopontin, fibrillin, thrombospondin, ADAM, COMP, L1 |
|
α6β1 |
Laminin, thrombospondin, ADAM, Cyr61 |
|
α7β1 |
Laminin |
|
α8β1 |
Tenascin, fibronectin, osteopontin, vitronectin, LAP-TGF-β, nephronectin |
|
α9β1 |
Tenascin, VCAM-1, osteopontin, uPAR, plasmin, angiostatin, ADAM [25], VEGF-C, VEGF-D [26] |
|
α10β1 |
Laminin, collagen |
|
α11β1 |
Collagen |
|
αVβ1 |
LAP-TGF-β, fibronectin, osteopontin, L1 |
|
αLβ2 |
ICAM, ICAM-4 |
|
αMβ2 |
ICAM, iC3b, factor X, fibrinogen, ICAM-4, heparin |
|
αXβ2 |
ICAM, iC3b, fibrinogen, ICAM-4, heparin, collagen [27] |
|
αDβ2 |
ICAM, VCAM-1, fibrinogen, fibronectin, vitronectin, Cyr61, plasminogen |
|
αIIbβ3 |
Fibrinogen, thrombospondin,, fibronectin, vitronectin, vWF, Cyr61, ICAM-4, L1, CD40 ligand [28] |
|
αVβ3 |
Fibrinogen, vitronectin, vWF, thrombospondin, fibrillin, tenascin, PECAM-1, fibronectin, osteopontin, BSP, MFG-E8, ADAM-15, COMP, Cyr61, ICAM-4, MMP, FGF-2 [29], uPA [30], uPAR [31], L1, angiostatin [32], plasmin [33], cardiotoxin [34], LAP-TGF-β, Del-1 |
|
α6β4 |
Laminin |
|
αVβ5 |
Osteopontin, BSP, vitronectin, CCN3 [35], LAP-TGF-β |
|
αVβ6 |
LAP-TGF-β, fibronectin, osteopontin, ADAM |
|
α4β7 |
MAdCAM-1, VCAM-1, fibronectin, osteopontin |
|
αEβ7 |
E-cadherin |
|
αVβ8 |
LAP-TGF-β |
|
|
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References are included for recently discovered ligands only. Abbreviations: ADAM, a disintegrin and metalloprotease; BSP, bone sialic protein; CCN3, an extracellular matrix protein; COMP, cartilage oligomeric matrix protein; Cyr61, cysteine-rich protein 61; L1, CD171; LAP-TGF-β, TGF-β latency-associated peptide; iC3b, inactivated complement component 3; PECAM-1, platelet and endothelial cell adhesion molecule 1; uPA, urokinase; uPAR, urokinase receptor; VEGF, vascular endothelial growth factor; vWF, von Willebrand Factor. |
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Takada et al. Genome Biology 2007 8:215 doi:10.1186/gb-2007-8-5-215 |
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