Table 2

Ligand-binding specificities of human integrins

Integrins

Ligands


α1β1

Laminin, collagen

α2β1

Laminin, collagen, thrombospondin, E-cadherin, tenascin

α3β1

Laminin, thrombospondin, uPAR

α4β1

Thrombospondin, MAdCAM-1, VCAM-1, fibronectin, osteopontin, ADAM, ICAM-4

α5β1

Fibronectin, osteopontin, fibrillin, thrombospondin, ADAM, COMP, L1

α6β1

Laminin, thrombospondin, ADAM, Cyr61

α7β1

Laminin

α8β1

Tenascin, fibronectin, osteopontin, vitronectin, LAP-TGF-β, nephronectin

α9β1

Tenascin, VCAM-1, osteopontin, uPAR, plasmin, angiostatin, ADAM [25], VEGF-C, VEGF-D [26]

α10β1

Laminin, collagen

α11β1

Collagen

αVβ1

LAP-TGF-β, fibronectin, osteopontin, L1

αLβ2

ICAM, ICAM-4

αMβ2

ICAM, iC3b, factor X, fibrinogen, ICAM-4, heparin

αXβ2

ICAM, iC3b, fibrinogen, ICAM-4, heparin, collagen [27]

αDβ2

ICAM, VCAM-1, fibrinogen, fibronectin, vitronectin, Cyr61, plasminogen

αIIbβ3

Fibrinogen, thrombospondin,, fibronectin, vitronectin, vWF, Cyr61, ICAM-4, L1, CD40 ligand [28]

αVβ3

Fibrinogen, vitronectin, vWF, thrombospondin, fibrillin, tenascin, PECAM-1, fibronectin, osteopontin, BSP, MFG-E8, ADAM-15, COMP, Cyr61, ICAM-4, MMP, FGF-2 [29], uPA [30], uPAR [31], L1, angiostatin [32], plasmin [33], cardiotoxin [34], LAP-TGF-β, Del-1

α6β4

Laminin

αVβ5

Osteopontin, BSP, vitronectin, CCN3 [35], LAP-TGF-β

αVβ6

LAP-TGF-β, fibronectin, osteopontin, ADAM

α4β7

MAdCAM-1, VCAM-1, fibronectin, osteopontin

αEβ7

E-cadherin

αVβ8

LAP-TGF-β


References are included for recently discovered ligands only. Abbreviations: ADAM, a disintegrin and metalloprotease; BSP, bone sialic protein; CCN3, an extracellular matrix protein; COMP, cartilage oligomeric matrix protein; Cyr61, cysteine-rich protein 61; L1, CD171; LAP-TGF-β, TGF-β latency-associated peptide; iC3b, inactivated complement component 3; PECAM-1, platelet and endothelial cell adhesion molecule 1; uPA, urokinase; uPAR, urokinase receptor; VEGF, vascular endothelial growth factor; vWF, von Willebrand Factor.

Takada et al. Genome Biology 2007 8:215   doi:10.1186/gb-2007-8-5-215