Table 3 |
||||
|
Phenotypes of deletions of integrin subunits in the mouse |
||||
|
Integrin subunit |
Viability |
Fertility |
Phenotype |
Reference |
|
|
||||
|
α1 |
+ |
+ |
Defects in bone healing and reduced tumor angiogenesis |
[36] |
|
α2 |
+ |
+ |
Reduced branching morphogenesis and platelet adhesion |
[37] |
|
α3 |
Perinatal lethal |
+ |
Kidney, lung, and skin defects |
[38] |
|
α4 |
Embryonic lethal |
- |
Placental and heart defects |
[39] |
|
α5 |
Embryonic lethal |
- |
Mesodermal and vascular defects |
[40] |
|
α6 |
Perinatal lethal |
+ |
Epidermal detachment, defect in neurogenesis |
[41] |
|
α7 |
+ |
+ |
Muscular dystrophy |
[42] |
|
α8 |
Perinatal lethal |
+ |
Kidney defect |
[43] |
|
α9 |
Perinatal lethal |
+ |
Chylothorax (defect in lymphatic drainage) |
[44] |
|
αv |
Embryonic and perinatal lethal |
+ |
Cerebral hemorrhage |
[45] |
|
αM |
+ |
+ |
Neutrophil adhesion and degranulation |
[46] |
|
αL |
+ |
+ |
Neutrophil emigration |
[47] |
|
αD |
+ |
+ |
Reduced T-cell response and T-cell phenotypic changes |
[48] |
|
αE |
+ |
+ |
Skin inflammation |
[49] |
|
β1 |
Embryonic lethal |
- |
Fails to gastrulate |
[45,50] |
|
β2 |
+ |
+ |
Leukocyte adhesion deficiency |
[51] |
|
β3 |
+ |
+ |
Platelet defect |
[52] |
|
β4 |
Perinatal lethal |
+ |
Epidermal detachment |
[53] |
|
β5 |
+ |
+ |
Accelerated age-related blindness |
[54] |
|
β6 |
+ |
+ |
Inflammation in skin and lungs |
[55] |
|
β7 |
+ |
+ |
Gut-associated lymphocyte defects |
[56] |
|
β8 |
Embryonic and perinatal lethal |
+ |
Cerebral hemorrhage |
[57] |
|
|
||||
|
Takada et al. Genome Biology 2007 8:215 doi:10.1186/gb-2007-8-5-215 |
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