Table 3

Phenotypes of deletions of integrin subunits in the mouse

Integrin subunit

Viability

Fertility

Phenotype

Reference


α1

+

+

Defects in bone healing and reduced tumor angiogenesis

[36]

α2

+

+

Reduced branching morphogenesis and platelet adhesion

[37]

α3

Perinatal lethal

+

Kidney, lung, and skin defects

[38]

α4

Embryonic lethal

-

Placental and heart defects

[39]

α5

Embryonic lethal

-

Mesodermal and vascular defects

[40]

α6

Perinatal lethal

+

Epidermal detachment, defect in neurogenesis

[41]

α7

+

+

Muscular dystrophy

[42]

α8

Perinatal lethal

+

Kidney defect

[43]

α9

Perinatal lethal

+

Chylothorax (defect in lymphatic drainage)

[44]

αv

Embryonic and perinatal lethal

+

Cerebral hemorrhage

[45]

αM

+

+

Neutrophil adhesion and degranulation

[46]

αL

+

+

Neutrophil emigration

[47]

αD

+

+

Reduced T-cell response and T-cell phenotypic changes

[48]

αE

+

+

Skin inflammation

[49]

β1

Embryonic lethal

-

Fails to gastrulate

[45,50]

β2

+

+

Leukocyte adhesion deficiency

[51]

β3

+

+

Platelet defect

[52]

β4

Perinatal lethal

+

Epidermal detachment

[53]

β5

+

+

Accelerated age-related blindness

[54]

β6

+

+

Inflammation in skin and lungs

[55]

β7

+

+

Gut-associated lymphocyte defects

[56]

β8

Embryonic and perinatal lethal

+

Cerebral hemorrhage

[57]


Takada et al. Genome Biology 2007 8:215   doi:10.1186/gb-2007-8-5-215