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Highly Accessed Correspondence

Conversion of amino-acid sequence in proteins to classical music: search for auditory patterns

Rie Takahashi* and Jeffrey H Miller

Author Affiliations

Department of Microbiology, Immunology and Molecular Genetics and the Molecular Biology Institute, University of California, Los Angeles, CA 90095-1489, USA

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Genome Biology 2007, 8:405  doi:10.1186/gb-2007-8-5-405

Published: 3 May 2007

Abstract

We have converted genome-encoded protein sequences into musical notes to reveal auditory patterns without compromising musicality. We derived a reduced range of 13 base notes by pairing similar amino acids and distinguishing them using variations of three-note chords and codon distribution to dictate rhythm. The conversion will help make genomic coding sequences more approachable for the general public, young children, and vision-impaired scientists.