Table 7

Estimation of the subcellular proteomes of eight eukaryotic organisms

Yeast (S. cerevisiae)

Worm (C. elegans)

Fruitfly (D. melano)

Mosquito (A. gambiae)

Zebrafish (D. rerio)

Chicken (G. gallus)

Mouse (M. musculus)

Human (H. sapiens)

Range


Proteome

5,799

22,400

13,649

15,145

13,803

5,394

33,043

38,149

GO annotated

5,486

12,357

9,997

8,847

10,106

4,363

23,744

24,638

% ngLOC coverage

97.48

94.92

96.73

97.94

98.64

9,9.82

94.79

94.52

94.79-99.82

Proteome estimated

5,653

21,262

13,203

14,833

13,616

5,384

31,320

36,059


% CYT

15.22

14.80

12.74

14.43

15.01

13.66

13.44

14.14

12.74-15.22

% CSK

1.07

1.19

1.05

1.11

1.31

1.24

1.50

1.48

1.05-1.50

% END

2.71

3.47

2.85

3.25

3.34

2.53

2.99

3.04

2.53-3.47

% EXC

8.88

12.60

12.26

14.28

9.91

12.65

11.52

11.71

8.88-14.28

% GOL

1.48

1.31

1.40

1.07

1.68

1.47

1.52

1.56

1.07-1.68

% LYS

0.11

0.58

0.55

0.53

0.65

0.44

0.59

0.67

0.11-0.67

% MIT

9.55

5.84

4.86

5.52

4.72

4.16

4.24

4.80

4.16-9.55

% NUC

33.53

29.75

37.38

29.50

30.31

28.24

27.35

28.38

27.35-37.38

% PLA

16.19

24.41

20.06

21.36

21.66

22.78

27.18

24.08

16.19-27.18

% POX

0.54

0.66

0.42

0.48

0.51

0.25

0.44

0.46

0.25-0.66


% Single-localized

89.29

94.60

93.59

91.53

89.11

87.42

90.77

90.32

% Multi-localized

10.71

5.40

6.41

8.47

10.89

12.58

9.23

9.68

% CYT-NUC

6.49

2.36

2.76

3.44

5.40

6.27

4.51

4.74


This chart presents the location-wise percentages of the proteome predicted to localize into one organelle. (For example, 9.55% of the yeast proteome is localized to the mitochrondria only.) These percentages sum to the total size of the proteome estimated to be single-localized. We also present the estimated percentage of the proteome that is localized to multiple organelles. The percentage of the proteome estimated to localize to both the cytoplasm and nucleus is also displayed. The coverage is determined with a confidence score (CS) threshold of 15. Multi-localized sequences are determined with a multi-localized confidence score (MLCS) threshold of 60. CSK, cytoskeleton; CYT, cytoplasm; END, endoplasmic reticulum; EXC, extracellular; GO, Gene Ontology; GOL, golgi; LYS, lysosome; MIT, mitochondria; NUC, nucleus; PLA, plasma membrane; POX, perixosome.

King and Guda Genome Biology 2007 8:R68   doi:10.1186/gb-2007-8-5-r68

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