Marked variation in susceptibility to UVC-induced DNA damage in different life stages of C elegans. The UVC dose and life stage both had significant effects on induction of nuclear and mitochondrial lesions (P < 0.0001 for main effects of both), but no difference was observed between the nuclear and mitochondrial genomes (P = 0.9218 for main effect of genome) in a three-factor analysis of variance. All life stages and doses were statistically distinct from each other (P < 0.0001 in all cases, Fisher's protected least significant difference [FPLSD]), except the adult stages (P > 0.05 for all pair-wise comparisons, FPLSD). n = 3 for each column; error bars represent standard errors of the mean.
Meyer et al. Genome Biology 2007 8:R70 doi:10.1186/gb-2007-8-5-r70