Table 2 |
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mRNA ratios for NER and NER-related genes in embryonic, young, and aging adult glp-1 nematodes raised at 25°C |
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Normalized expression values |
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|
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|
Human NER and NER-related genes |
C elegans homologs |
Embryonic glp-1s |
Young adult glp-1s |
Aging adult glp-1s |
|
|
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|
XPC |
Y76B12C.2 |
5.589 (4.369 to 6.619)a |
0.937 (0.621 to 1.491)b |
1.526 (1.347 to 1.729) |
|
RAD23A/B |
ZK20.3 |
1.109 (1.024 to 1.212) |
0.984 (0.776 to 1.204) |
1.057 (1.01 to 1.106) |
|
CETN2 |
T21H3.3 |
0.949 (0.76 to 1.125) |
0.945 (0.591 to 1.357) |
1.423 (1.244 to 1.628) |
|
XPA |
K07G5.2 |
3.107 (2.701 to 3.446)a |
0.918 (0.585 to 1.576) |
1.42 (1.33 to 1.516) |
|
RPA1 |
F18A1.5 |
8.712 (7.521 to 10.17)a |
0.995 (0.903 to 1.136) |
1.701 (1.633 to 1.772) |
|
RPA2 |
M04F3.1 |
4.133 (3.253 to 4.985)a |
0.984 (0.769 to 1.179) |
0.963 (0.743 to 1.247) |
|
ERCC3 (XPB) |
Y66D12A.15 |
1.352 (1.286 to 1.458) |
0.994 (0.856 to 1.119) |
1.789 (1.539 to 2.08) |
|
ERCC2 (XPD) |
Y50D7A.2 |
1.47 (1.262 to 1.865) |
0.976 (0.71 to 1.203) |
0.281 (0.279 to 0.283)b |
|
GTF2H1 |
R02D3.3 |
3.791 (3.502 to 4.171)a |
0.972 (0.741 to 1.325) |
1.016 (0.915 to 1.128) |
|
GTF2H2 |
T16H12.4 |
5.594 (4.509 to 6.348)a |
0.973 (0.746 to 1.319)b |
1.444 (0.977 to 2.135) |
|
GTF2H3 |
ZK1128.4 |
1.326 (1.193 to 1.464) |
0.917 (0.653 to 1.615) |
1.611 (1.361 to 1.906) |
|
GTF2H4 |
Y73F8A.24 |
1.78 (1.704 to 1.891) |
0.955 (0.716 to 1.44) |
1.304 (1.13 to 1.506) |
|
GTF2H5 (TTDA) |
Y55B1AL.2 |
0.917 (0.733 to 1.083) |
0.929 (0.598 to 1.521) |
0.839 (0.783 to 0.898) |
|
CDK7 |
Y39G10AL.3 |
3.504 (3.173 to 4.126)a |
0.967 (0.79 to 1.383) |
1.467 (1.389 to 1.55) |
|
CCNH |
Y49F6B.1 |
23.67 (13.54 to 36.68)a |
0.963 (0.727 to 1.386)b |
1.553 (1.245 to 1.938)b |
|
MNAT1 |
F53G2.7 |
1.563 (1.521 to 1.639) |
0.884 (0.597 to 1.735) |
1.9 (1.839 to 1.963) |
|
ERCC5 (XPG) |
F57B10.6 |
1.073 (1.02 to 1.132) |
0.988 (0.796 to 1.146) |
1.149 (1.056 to 1.251) |
|
ERCC1 |
F10G8.7 |
1.018 (0.852 to 1.243) |
0.957 (0.618 to 1.209) |
0.857 (0.855 to 0.859) |
|
ERCC4 (XPF) |
C47D12.8 |
2.836 (2.41 to 3.451)a |
0.992 (0.826 to 1.097)b |
1.06 (0.909 to 1.237)b |
|
LIG1 |
C29A12.3a |
18.19 (14.65 to 23.2)a |
0.997 (0.904 to 1.084) |
0.752 (0.687 to 0.823) |
|
CKN1 (ERCC8) |
K07A1.12 |
15.04 (10.95 to 18.83)a |
0.971 (0.707 to 1.282) |
1.558 (1.269 to 1.911) |
|
ERCC6 (CSB) |
F53H4.1 |
0.479 (0.425 to 0.587) |
0.995 (0.874 to 1.128)b |
0.57 (0.551 to 0.589)b |
|
XAB2 (HCNP) |
C50F2.3 |
7.011 (5.565 to 8.512)a |
0.993 (0.901 to 1.172) |
1.511 (1.494 to 1.527) |
|
DDB1 |
M18.5 |
1.499 (1.365 to 1.596) |
0.993 (0.841 to 1.115) |
1.768 (1.661 to 1.883) |
|
DDB2 |
C18E3.5 |
6.884 (5.14 to 8.339)a |
0.989 (0.851 to 1.203)b |
1.419 (1.419 to 1.42) |
|
TFF2 |
T23H2.3a |
1.785 (1.298 to 2.093) |
0.94 (0.66 to 1.505)b |
0.907 (0.778 to 1.057) |
|
MMS19L (MMS19) |
C24G6.3 |
1.271 (0.947 to 1.72) |
0.996 (0.887 to 1.084) |
1.214 (1.024 to 1.439) |
|
|
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|
Shown are mRNA ratios for nucleotide excision repair (NER) and NER-related genes in embryonic, young (1 day after L4 molt), and aging (6 days after L4 molt) adult glp-1 nematodes raised at 25°C. aValues that are significantly different (P < 0.001 by Rosetta Resolver) for embryos compared with young adults. No statistically significant differences between young and aging adults occurred. bRaw fluorescence signals flagged by GeneSpring as absent (below reliable detection). |
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|
Meyer et al. Genome Biology 2007 8:R70 doi:10.1186/gb-2007-8-5-r70 |
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