Table 3

Major biologic functions altered in aging versus young glp-1 adults

Biologic process/molecular functiona

mRNA levels in aging versus young adult glp-1s

Proportion changedb

P valueb


Larval development

Decreased

112/842

<0.0001

Ion transport

Decreased

113/504

<0.0001

Generation of precursor metabolites and energy

Decreased

78/474

<0.0001

Structural constituents of cuticle

Decreased

88/144

<0.0001

Lipid metabolism

Decreased

24/145

<0.0001

Oxidative phosphorylation

Decreased

13/44

<0.0001

Aging (C elegans)

Decreased

12/58

0.003

Catalytic activity

Decreased

215/2734

0.0004

Glycolysis

Decreased

4/15

0.014

Positive regulation of growth

Increased

124/928

<0.0001

Cytoskeleton

Increased

21/108

0.0003

Rab-related GTPase protein-mediated vesicular trafficking

Increased

16/72

0.0003

Aging (C elegans)

Increased

10/58

0.004

Osmoregulation

Increased

21/137

0.007

Locomotion

Increased

24/144

0.001


Shown are major biologic functions altered in aging (6-day) as compared with young (1-day) glp-1 adults. aListed Gene Ontologies were identified as different in young and aging glp-1s in at least two of three different bioinformatic analyses. bProportion changed and p values are as determined by GOMiner. Complete Gene Ontology analyses are given in Additional data files 3, 4 (parts A and B), and 5. I changed the format slightly to avoid breaking up "glp-1s".

Meyer et al. Genome Biology 2007 8:R70   doi:10.1186/gb-2007-8-5-r70

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