Table 3 |
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Major biologic functions altered in aging versus young glp-1 adults |
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|
Biologic process/molecular functiona |
mRNA levels in aging versus young adult glp-1s |
Proportion changedb |
P valueb |
|
|
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|
Larval development |
Decreased |
112/842 |
<0.0001 |
|
Ion transport |
Decreased |
113/504 |
<0.0001 |
|
Generation of precursor metabolites and energy |
Decreased |
78/474 |
<0.0001 |
|
Structural constituents of cuticle |
Decreased |
88/144 |
<0.0001 |
|
Lipid metabolism |
Decreased |
24/145 |
<0.0001 |
|
Oxidative phosphorylation |
Decreased |
13/44 |
<0.0001 |
|
Aging (C elegans) |
Decreased |
12/58 |
0.003 |
|
Catalytic activity |
Decreased |
215/2734 |
0.0004 |
|
Glycolysis |
Decreased |
4/15 |
0.014 |
|
Positive regulation of growth |
Increased |
124/928 |
<0.0001 |
|
Cytoskeleton |
Increased |
21/108 |
0.0003 |
|
Rab-related GTPase protein-mediated vesicular trafficking |
Increased |
16/72 |
0.0003 |
|
Aging (C elegans) |
Increased |
10/58 |
0.004 |
|
Osmoregulation |
Increased |
21/137 |
0.007 |
|
Locomotion |
Increased |
24/144 |
0.001 |
|
|
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Shown are major biologic functions altered in aging (6-day) as compared with young (1-day) glp-1 adults. aListed Gene Ontologies were identified as different in young and aging glp-1s in at least two of three different bioinformatic analyses. bProportion changed and p values are as determined by GOMiner. Complete Gene Ontology analyses are given in Additional data files 3, 4 (parts A and B), and 5. I changed the format slightly to avoid breaking up "glp-1s". |
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Meyer et al. Genome Biology 2007 8:R70 doi:10.1186/gb-2007-8-5-r70 |
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