Table 1 |
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Genes strongly dysregulated in P16 Nfia-/- mice |
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|
Affymetrix probe set ID |
fold change |
P value |
Gene (encoded protein) |
|
|
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|
92939_at |
-3.22 |
0.0026 |
Gabra6 (γ-aminobutyric acid [GABA]-A receptor, subunit α6) |
|
92940_s_at |
-2.94 |
0.0018 |
Gabra6 (GABA-A receptor, subunit α6) |
|
100068_at |
-3.14 |
0.0075 |
Aldh1a1 (aldehyde dehydrogenase family 1, subfamily A1) |
|
99089_at |
-2.43 |
0.0007 |
Mal (myelin and lymphocyte protein, T-cell differentiation protein) |
|
101887_at |
-2.24 |
0.0007 |
Agt (angiotensinogen precursor, gene, exon 5 and complete coding sequence) |
|
93137_at |
-2.21 |
0.0003 |
Ntsr2 (neurotensin receptor 2) |
|
103023_at |
-2.13 |
0.0003 |
Lcat (lecithin cholesterol acyltransferase) |
|
99046_at |
-2.11 |
0.0080 |
Mobp (myelin-associated oligodendrocytic basic protein) |
|
100536_at |
-2.10 |
0.0048 |
Mobp (myelin-associated oligodendrocytic basic protein) |
|
99047_at |
-1.99 |
0.0011 |
Mobp (myelin-associated oligodendrocytic basic protein) |
|
99048_g_at |
-1.98 |
0.0022 |
Mobp (myelin-associated oligodendrocytic basic protein) |
|
94391_at |
-2.07 |
0.0014 |
Gjb6 (gap junction membrane channel protein β6) |
|
102571_at |
-1.81 |
0.0194 |
Gjb6 (gap junction membrane channel protein β6) |
|
97089_at |
-2.06 |
0.0128 |
Folh1 (folate hydrolase) |
|
160754_at |
-1.97 |
0.0059 |
Pygm (muscle glycogen phosphorylase) |
|
103987_at |
-1.95 |
0.0044 |
Mog (myelin oligodendrocyte glycoprotein) |
|
101467_at |
-1.90 |
0.0018 |
S100b (mouse S100 β protein exons 1 to 3, complete cds.) |
|
100002_at |
-1.89 |
0.0016 |
Itih3 (inter-α trypsin inhibitor, heavy chain 3) |
|
95286_at |
-1.88 |
0.0112 |
Clu (clusterin) |
|
161294_f_at |
-1.63 |
0.0093 |
Clu (clusterin) |
|
100494_at |
-1.87 |
0.0003 |
Fgf1 (fibroblast growth factor 1) |
|
97317_at |
-1.81 |
0.0003 |
Enpp2 (ectonucleotide pyrophosphatase/phosphodiesterase 2) |
|
94144_g_at |
-1.71 |
0.0053 |
GFAP (mouse gene for glial fibrillary acidic protein) |
|
94143_at |
-1.56 |
0.0279 |
GFAP (mouse gene for glial fibrillary acidic protein) |
|
160065_s_at |
-1.70 |
0.0066 |
Csrp1 (cysteine and glycine-rich protein 1) |
|
92608_at |
-1.63 |
0.0194 |
Csrp1 (cysteine and glycine-rich protein 1) |
|
94057_g_at |
-1.70 |
0.0227 |
Scd1 (stearoyl-CoA desaturase; Mouse stearoyl-CoA desaturase gene, exon 6) |
|
94056_at |
-1.68 |
0.0093 |
Scd1 (stearoyl-CoA desaturase; Mouse stearoyl-CoA desaturase gene, exon 6) |
|
161610_at |
-1.69 |
0.0053 |
Ndrg2 (N-myc downstream regulated 2) |
|
96088_at |
-1.68 |
0.0021 |
Ndrg2 (N-myc downstream regulated 2) |
|
94079_at |
-1.68 |
0.0035 |
Sept4 (septin 4) |
|
92717_at |
-1.68 |
0.0135 |
Neurod1 (Neurogenic differentiation 1) |
|
93389_at |
-1.67 |
0.0026 |
Prom1 (prominin 1) |
|
93390_g_at |
-1.67 |
0.0043 |
Prom1 (prominin 1) |
|
98872_at |
-1.67 |
0.0129 |
Ugt8 (UDP-galactose:ceramide galactosyltransferase [Cgt] gene) |
|
93573_at |
-1.67 |
0.0396 |
Mt1 (mouse gene for metallothionein-I [three exons]) |
|
96720_f_at |
-1.66 |
0.0145 |
Pvalb (Parvalbumin) |
|
100441_s_at |
-1.64 |
0.0014 |
Ank1 (ankyrin 1, erythroid) |
|
103429_i_at |
-1.61 |
0.0060 |
(Expressed sequence AL024210) |
|
93750_at |
-1.58 |
0.0011 |
Gsn (murine gelsolin protein; mouse gelsolin gene, complete cds.) |
|
100044_at |
-1.58 |
0.0196 |
Cldn11 (claudin 11) |
|
93159_at |
-1.54 |
0.0065 |
Expressed sequence tags |
|
92802_s_at |
-1.54 |
0.0333 |
Plp1 (Proteolipid protein [myelin] 1) |
|
92932_at |
-1.52 |
0.0059 |
Cbln1 (cerebellin 1 precursor protein) |
|
102405_at |
-1.52 |
0.0111 |
MAG (myelin-associated glycoprotein) |
|
98338_at |
-1.52 |
0.0363 |
En2 (engrailed 2) |
|
98025_at |
-1.51 |
0.0147 |
Evi2a (ecotropic viral integration site 2a) |
|
93664_at |
-1.51 |
0.0272 |
Atp1b2 (ATPase, Na+/K+ transporting, β2 polypeptide) |
|
102773_at |
-1.50 |
0.0246 |
Car8 (carbonic anhydrase 8) |
|
103046_at |
-1.50 |
0.0079 |
Car4 (Mus musculus carbonic anhydrase IV gene, complete cds.) |
|
95654_at |
1.50 |
0.0376 |
Clic1 (chloride intracellular channel 1) |
|
92380_r_at |
1.58 |
0.0092 |
Ptprz1 (protein tyrosine phosphatase, receptor type, Z polypeptide 1) |
|
92379_f_at |
1.82 |
0.0020 |
Ptprz1 (protein tyrosine phosphatase, receptor type, Z polypeptide 1) |
|
98394_at |
1.58 |
0.0401 |
Dlx1 (distal-less homeobox 1) |
|
97527_at |
1.65 |
0.0083 |
Cks2 (CDC28 protein kinase regulatory subunit 2) |
|
97520_s_at |
1.66 |
0.0217 |
Nnat (neuronatin) |
|
98038_at |
1.72 |
0.0004 |
Hmgb3 (high mobility group box 3) |
|
101503_at |
1.73 |
0.0339 |
Dpysl3 (dihydropyrimidinase-like 3) |
|
93028_at |
1.77 |
0.0278 |
H19 (H19 fetal liver mRNA) |
|
100600_at |
1.84 |
0.0030 |
CD24a (CD24a antigen) |
|
102307_at |
1.87 |
0.0085 |
Dcx (doublecortin) |
|
101631_at |
1.88 |
0.0169 |
Sox11 (SRY-box containing gene 11) |
|
93669_f_at |
2.22 |
0.0029 |
Sox11 (SRY-box containing gene 11) |
|
93250_r_at |
1.92 |
0.0004 |
Hmgb2 (high mobility group box 2) |
|
96041_at |
1.98 |
0.0037 |
Rbm3 (RNA binding motif protein 3) |
|
98967_at |
2.59 |
0.0002 |
Fabp7 (fatty acid binding protein 7, brain) |
|
|
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Provided is a list of genes significantly dysregulated more than 1.5-fold in Nfia-/- mouse brain relative to Nfia+/+ mice at postnatal day 16 (P16). Note that several genes (for instance, Gabra6) are represented by more than one Affymetrix probe set. |
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Wong et al. Genome Biology 2007 8:R72 doi:10.1186/gb-2007-8-5-r72 |
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