Table 1

Genes strongly dysregulated in P16 Nfia-/- mice

Affymetrix probe set ID

fold change

P value

Gene (encoded protein)


92939_at

-3.22

0.0026

Gabra6 (γ-aminobutyric acid [GABA]-A receptor, subunit α6)

92940_s_at

-2.94

0.0018

Gabra6 (GABA-A receptor, subunit α6)

100068_at

-3.14

0.0075

Aldh1a1 (aldehyde dehydrogenase family 1, subfamily A1)

99089_at

-2.43

0.0007

Mal (myelin and lymphocyte protein, T-cell differentiation protein)

101887_at

-2.24

0.0007

Agt (angiotensinogen precursor, gene, exon 5 and complete coding sequence)

93137_at

-2.21

0.0003

Ntsr2 (neurotensin receptor 2)

103023_at

-2.13

0.0003

Lcat (lecithin cholesterol acyltransferase)

99046_at

-2.11

0.0080

Mobp (myelin-associated oligodendrocytic basic protein)

100536_at

-2.10

0.0048

Mobp (myelin-associated oligodendrocytic basic protein)

99047_at

-1.99

0.0011

Mobp (myelin-associated oligodendrocytic basic protein)

99048_g_at

-1.98

0.0022

Mobp (myelin-associated oligodendrocytic basic protein)

94391_at

-2.07

0.0014

Gjb6 (gap junction membrane channel protein β6)

102571_at

-1.81

0.0194

Gjb6 (gap junction membrane channel protein β6)

97089_at

-2.06

0.0128

Folh1 (folate hydrolase)

160754_at

-1.97

0.0059

Pygm (muscle glycogen phosphorylase)

103987_at

-1.95

0.0044

Mog (myelin oligodendrocyte glycoprotein)

101467_at

-1.90

0.0018

S100b (mouse S100 β protein exons 1 to 3, complete cds.)

100002_at

-1.89

0.0016

Itih3 (inter-α trypsin inhibitor, heavy chain 3)

95286_at

-1.88

0.0112

Clu (clusterin)

161294_f_at

-1.63

0.0093

Clu (clusterin)

100494_at

-1.87

0.0003

Fgf1 (fibroblast growth factor 1)

97317_at

-1.81

0.0003

Enpp2 (ectonucleotide pyrophosphatase/phosphodiesterase 2)

94144_g_at

-1.71

0.0053

GFAP (mouse gene for glial fibrillary acidic protein)

94143_at

-1.56

0.0279

GFAP (mouse gene for glial fibrillary acidic protein)

160065_s_at

-1.70

0.0066

Csrp1 (cysteine and glycine-rich protein 1)

92608_at

-1.63

0.0194

Csrp1 (cysteine and glycine-rich protein 1)

94057_g_at

-1.70

0.0227

Scd1 (stearoyl-CoA desaturase; Mouse stearoyl-CoA desaturase gene, exon 6)

94056_at

-1.68

0.0093

Scd1 (stearoyl-CoA desaturase; Mouse stearoyl-CoA desaturase gene, exon 6)

161610_at

-1.69

0.0053

Ndrg2 (N-myc downstream regulated 2)

96088_at

-1.68

0.0021

Ndrg2 (N-myc downstream regulated 2)

94079_at

-1.68

0.0035

Sept4 (septin 4)

92717_at

-1.68

0.0135

Neurod1 (Neurogenic differentiation 1)

93389_at

-1.67

0.0026

Prom1 (prominin 1)

93390_g_at

-1.67

0.0043

Prom1 (prominin 1)

98872_at

-1.67

0.0129

Ugt8 (UDP-galactose:ceramide galactosyltransferase [Cgt] gene)

93573_at

-1.67

0.0396

Mt1 (mouse gene for metallothionein-I [three exons])

96720_f_at

-1.66

0.0145

Pvalb (Parvalbumin)

100441_s_at

-1.64

0.0014

Ank1 (ankyrin 1, erythroid)

103429_i_at

-1.61

0.0060

(Expressed sequence AL024210)

93750_at

-1.58

0.0011

Gsn (murine gelsolin protein; mouse gelsolin gene, complete cds.)

100044_at

-1.58

0.0196

Cldn11 (claudin 11)

93159_at

-1.54

0.0065

Expressed sequence tags

92802_s_at

-1.54

0.0333

Plp1 (Proteolipid protein [myelin] 1)

92932_at

-1.52

0.0059

Cbln1 (cerebellin 1 precursor protein)

102405_at

-1.52

0.0111

MAG (myelin-associated glycoprotein)

98338_at

-1.52

0.0363

En2 (engrailed 2)

98025_at

-1.51

0.0147

Evi2a (ecotropic viral integration site 2a)

93664_at

-1.51

0.0272

Atp1b2 (ATPase, Na+/K+ transporting, β2 polypeptide)

102773_at

-1.50

0.0246

Car8 (carbonic anhydrase 8)

103046_at

-1.50

0.0079

Car4 (Mus musculus carbonic anhydrase IV gene, complete cds.)

95654_at

1.50

0.0376

Clic1 (chloride intracellular channel 1)

92380_r_at

1.58

0.0092

Ptprz1 (protein tyrosine phosphatase, receptor type, Z polypeptide 1)

92379_f_at

1.82

0.0020

Ptprz1 (protein tyrosine phosphatase, receptor type, Z polypeptide 1)

98394_at

1.58

0.0401

Dlx1 (distal-less homeobox 1)

97527_at

1.65

0.0083

Cks2 (CDC28 protein kinase regulatory subunit 2)

97520_s_at

1.66

0.0217

Nnat (neuronatin)

98038_at

1.72

0.0004

Hmgb3 (high mobility group box 3)

101503_at

1.73

0.0339

Dpysl3 (dihydropyrimidinase-like 3)

93028_at

1.77

0.0278

H19 (H19 fetal liver mRNA)

100600_at

1.84

0.0030

CD24a (CD24a antigen)

102307_at

1.87

0.0085

Dcx (doublecortin)

101631_at

1.88

0.0169

Sox11 (SRY-box containing gene 11)

93669_f_at

2.22

0.0029

Sox11 (SRY-box containing gene 11)

93250_r_at

1.92

0.0004

Hmgb2 (high mobility group box 2)

96041_at

1.98

0.0037

Rbm3 (RNA binding motif protein 3)

98967_at

2.59

0.0002

Fabp7 (fatty acid binding protein 7, brain)


Provided is a list of genes significantly dysregulated more than 1.5-fold in Nfia-/- mouse brain relative to Nfia+/+ mice at postnatal day 16 (P16). Note that several genes (for instance, Gabra6) are represented by more than one Affymetrix probe set.

Wong et al. Genome Biology 2007 8:R72   doi:10.1186/gb-2007-8-5-r72

Open Data