Table 3

Genes related to oligodendrocyte differentiation are differentially expressed in Nfia^-/- mice at P16

Gene name

Fold change of mRNA expression in Nfia^-/- versus Nfia^+/+ mice^a

Reference

Genes typically expressed in oligodendrocyte precursors or related to de-differentiation of precursor cells

Hmgb2

1.92

[45]

Sox2

1.28

[46]

Sox4

1.33/1.44

[47]

Sox11

1.88/2.22

[47]

Tenascin-C

1.47

[48]

Myef2^b

1.2

[39]

Genes typically expressed in mature oligodendrocytes or related to terminal oligodendrocyte differentiation

Mobp

-2.11/-2.10/-1.99/-1.98

[49]

Mal

-2.43

[50]

Mog

-1.95

[51]

Claudin 11

-1.67

[52]

Plp1

-1.58

[53]

Ugt8

-1.54/-1.45

[50]

Mag

-1.52

[53]

Dio2^c

-1.43

[38]

Car2

-1.35

[54]

^aAccording to microarray analysis; for genes represented by more than one probe set, the individual fold changes for each probe set are given. ^bIndirect link to oligodendrocyte maturation (My-EF2 can repress expression of myelin basic protein). ^cIndirect link to oligodendrocyte maturation (Dio2 catalyzes thyroxine to tri-iodothyronine conversion, and tri-iodothyronine triggers terminal differentiation of oligodendrocytes). P16, postnatal day 16.

Wong et al. Genome Biology 2007 8:R72   doi:10.1186/gb-2007-8-5-r72