Differences in transcriptional profiles of known copper and iron regulated genes between S. pombe and S. cerevisiae. The S. pombe genes implicated in copper or iron metabolism by homology with S. cerevisiae (Table 1) were compared with the set of genes that exhibited expression changes in response to changes in copper or iron levels. Overlaps between these lists indicate conserved regulation and are visualized in Venn diagrams. The central circle in each Venn diagram indicates the total number of differentially expressed genes in conditions of (a) low copper, (b) low iron, or (c) high copper. Individual gene clusters with a role in copper or iron metabolism are shown in different colors. The behavior of homologous genes in S. cerevisiae is shown in comparison. The temporal transcriptional profiles for overlapping segments in the Venn diagrams, representing conserved copper and iron dependent gene regulation, are visualized in graphs that plot the averaged expression ratio as a function of time.
Rustici et al. Genome Biology 2007 8:R73 doi:10.1186/gb-2007-8-5-r73