Figure 4.

S. cerevisiae ace1-Δ mutants fail to induce a core environmental stress response in response to high copper. (a) Transcriptional response of S. cerevisiae ace1-Δ mutants to excess copper (8 μmol/l CuSO₄). (b) Venn diagrams showing the overlap between differentially expressed genes in the ace1-Δ mutants (Figure 3a), and clusters of genes that are orthologs to the core environmental stress response in fission yeast, or known to be regulated in response to copper or iron. Venn diagrams and transcriptional profiles are colored as in Figure 2.