Expression of Cup1p in S. pombe reduces the effects of high copper stress. Diagram of expression patterns in fission yeast overexpressing S. cerevisiae CUP1 or an empty control vector (EV) after exposure to 2 μmol/l CuSO4 for 30 min. The profiles for wild-type (WT) fission yeast in response to 2 and 10 μmol/l CuSO4 are shown for comparison. Data are displayed for the set of 93 genes that were differentially expressed in the 2 μmol/l CuSO4 experiment after hierarchical clustering.
Rustici et al. Genome Biology 2007 8:R73 doi:10.1186/gb-2007-8-5-r73