Table 1 |
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|
Gene classes induced and repressed upon changes in S. pombe copper or iron status |
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|
Condition |
Induced |
Repressed |
||
|
|
||||
|
Classification |
Gene number |
Classification |
Gene number |
|
|
|
||||
|
Low copper (100 mmol/l BCS) |
Metal ion transport |
5 |
Oxidoreductases and dehydrogenases |
3 |
|
Peroxisomal proteins |
2 |
Flavoproteins |
2 |
|
|
Other transport |
1 |
Antioxidants |
2 |
|
|
Others |
3 |
|||
|
Low iron (300 mmol/l FZ) |
Metal ion transport |
8 |
Localized to the mitochondrion |
6 |
|
Other transport |
2 |
Transporters |
3 |
|
|
Peptide biosynthesis |
2 |
Metal metabolism |
2 |
|
|
Iron-Sulfur cluster assembly |
1 |
Iron/sulfur cluster proteins |
2 |
|
|
Others/Unknown |
19 |
Thiamine biosynthesis |
2 |
|
|
Others/unknown |
9 |
|||
|
High copper (2 mmol/l CuSO4) |
Protein folding/chaperone |
12 |
Transporters |
7 |
|
Antioxidants |
6 |
Amino acid metabolism and transport |
4 |
|
|
Sulphur amino acid biosynthesis |
6 |
Ribosomal proteins |
2 |
|
|
Carbohydrate metabolism |
4 |
Others/unknown |
11 |
|
|
Stress response |
4 |
|||
|
Iron uptake |
3 |
|||
|
Signaling and transcription regulation |
2 |
|||
|
Lipid biosynthesis |
2 |
|||
|
Peptide biosynthesis |
2 |
|||
|
Other/unknown |
28 |
|||
|
|
||||
|
BCS, bathocuproinedisulfonic acid; FZ, ferrozine. |
||||
|
Rustici et al. Genome Biology 2007 8:R73 doi:10.1186/gb-2007-8-5-r73 |
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