Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
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* Corresponding author: Charles M Perou cperou@med.unc.edu
- † Equal contributors
Genome Biology 2007, 8:R76 doi:10.1186/gb-2007-8-5-r76
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Primary research
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Christina N Bennett, Jeffrey E Green Breast Cancer Research 2008, 10:213 (11 September 2008) |
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Jason I Herschkowitz, Xiaping He, Cheng Fan, Charles M Perou Breast Cancer Research 2008, 10:R75 (9 September 2008) The functional loss of the retinoblastoma tumour suppressor, RB1, is common in basal-like tumours and may play a key role in their aggressive biology and unique therapeutic responses.
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PMC42, a breast progenitor cancer cell line, has normal-like mRNA and microRNA transcriptomes Anna Git, Inmaculada Spiteri, Cherie Blenkiron, Mark J Dunning, Jessica CM Pole, Suet-Feung Chin, Yanzhong Wang, James Smith, Frederick J Livesey, Carlos Caldas Breast Cancer Research 2008, 10:R54 (27 June 2008) Breast cancer cell line PMC42 is a good model for normal breast epithelium, providing a unique biological tool to study breast differentiation and the function of key miRNAs typically lost in cancer.
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Research
Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1 Mollie H Wright, Ana I Robles, Jason I Herschkowitz, Melinda G Hollingshead, Miriam R Anver, Charles M Perou, Lyuba Varticovski Molecular Cancer 2008, 7:29 (7 April 2008) |
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Mollie H Wright, Anna Calcagno, Crystal D Salcido, Marisa D Carlson, Suresh V Ambudkar, Lyuba Varticovski Breast Cancer Research 2008, 10:R10 (1 February 2008) Brca1-deficient mouse mammary tumours harbour heterogeneous cancer stem cell populations and CD44+/24- cells also identify human breast cancer stem cells; spheroid-forming assay may allow rapid screening of tumours for stem cell enrichment.
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EGFR associated expression profiles vary with breast tumor subtype Katherine A Hoadley, Victor J Weigman, Cheng Fan, Lynda R Sawyer, Xiaping He, Melissa A Troester, Carolyn I Sartor, Thais Rieger-House, Philip S Bernard, Lisa A Carey, Charles M Perou BMC Genomics 2007, 8:258 (31 July 2007) |