Table 1 |
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|
Summary of mouse mammary tumor models |
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| Tumor model |
No. of tumors |
Specificity of lesions |
Experimental oncogenic lesion(s) |
Strain |
Reference |
|
|
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| TgWAP-Myc |
13 |
WAP* |
cMyc overexpression |
FVB |
[60] |
| TgWAP-Int3 |
7 |
WAP |
Notch4 overexpression |
FVB |
[61] |
| TgWAP-T121 |
5 |
WAP |
pRb, p107, p130 inactivation |
B6D2 |
[37] |
| TgWAP-T121 |
2 |
WAP |
pRb, p107, p130 inactivation |
BALB/cJ |
[37] |
| TgWAP-Tag |
5 |
WAP |
SV40 L-T (pRb, p107, p130, p53, p300 inactivation, others); SV40 s-t |
C57Bl/6 |
[62] |
| TgC3(1)-Tag |
8 |
C3(1)† |
SV40 L-T (pRb, p107, p130, p53, p300 inactivation, others); SV40 s-t |
FVB |
[63] |
| TgMMTV-Neu |
10 |
MMTV‡ |
Unactivated rat Her2 overexpression |
FVB |
[64] |
| TgMMTV-Wnt1 |
11 |
MMTV |
Wnt 1 overexpression |
FVB |
[65] |
| TgMMTV-PyMT |
7 |
MMTV |
Py-MT (activation of Src, PI-3' kinase, and Shc) |
FVB |
[66] |
| TgMMTV-Cre;Brca1Co/Co;p53+/- |
10 |
MMTV |
Brca1 truncation mutant; p53 heterozygous null |
C57Bl/6 |
[67] |
| p53-/-transplanted |
5 |
None |
p53 inactivation |
BALB/cJ |
[68] |
| Medroxyprogesterone-DMBA-induced |
11 |
None |
Random DMBA-induced |
FVB |
[69] |
| p53+/-irradiated |
7 |
None |
p53 heterozygous null, random IR induced |
BALB/cJ |
[70] |
| Brca1+/-;p53+/-irradiated |
7 |
None |
Brca1 and p53 heterozygous null, random IR induced |
BALB/cJ |
[1] |
|
|
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|
*WAP, whey acidic protein promoter, commonly restricted to lactating mammary gland luminal cells. †C3(1), 5' flanking region of the C3(1) component of the rat prostate steroid binding protein, expressed in mammary ductal cells. ‡MMTV, mouse mammary tumor virus promoter, often expressed in virgin mammary gland epithelium, induced with lactation; often expressed at ectopic sites (for example, lymphoid cells, salivary gland, others). |
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|
Herschkowitz et al. Genome Biology 2007 8:R76 doi:10.1186/gb-2007-8-5-r76 |
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