Table 1

Summary of mouse mammary tumor models

Tumor model

No. of tumors

Specificity of lesions

Experimental oncogenic lesion(s)

Strain

Reference


TgWAP-Myc

13

WAP*

cMyc overexpression

FVB

[60]

TgWAP-Int3

7

WAP

Notch4 overexpression

FVB

[61]

TgWAP-T121

5

WAP

pRb, p107, p130 inactivation

B6D2

[37]

TgWAP-T121

2

WAP

pRb, p107, p130 inactivation

BALB/cJ

[37]

TgWAP-Tag

5

WAP

SV40 L-T (pRb, p107, p130, p53, p300 inactivation, others); SV40 s-t

C57Bl/6

[62]

TgC3(1)-Tag

8

C3(1)

SV40 L-T (pRb, p107, p130, p53, p300 inactivation, others); SV40 s-t

FVB

[63]

TgMMTV-Neu

10

MMTV

Unactivated rat Her2 overexpression

FVB

[64]

TgMMTV-Wnt1

11

MMTV

Wnt 1 overexpression

FVB

[65]

TgMMTV-PyMT

7

MMTV

Py-MT (activation of Src, PI-3' kinase, and Shc)

FVB

[66]

TgMMTV-Cre;Brca1Co/Co;p53+/-

10

MMTV

Brca1 truncation mutant; p53 heterozygous null

C57Bl/6

[67]

p53-/-transplanted

5

None

p53 inactivation

BALB/cJ

[68]

Medroxyprogesterone-DMBA-induced

11

None

Random DMBA-induced

FVB

[69]

p53+/-irradiated

7

None

p53 heterozygous null, random IR induced

BALB/cJ

[70]

Brca1+/-;p53+/-irradiated

7

None

Brca1 and p53 heterozygous null, random IR induced

BALB/cJ

[1]


*WAP, whey acidic protein promoter, commonly restricted to lactating mammary gland luminal cells. C3(1), 5' flanking region of the C3(1) component of the rat prostate steroid binding protein, expressed in mammary ductal cells. MMTV, mouse mammary tumor virus promoter, often expressed in virgin mammary gland epithelium, induced with lactation; often expressed at ectopic sites (for example, lymphoid cells, salivary gland, others).

Herschkowitz et al. Genome Biology 2007 8:R76   doi:10.1186/gb-2007-8-5-r76

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