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Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma

Bin Yan, Xinping Yang, Tin-Lap Lee, Jay Friedman, Jun Tang, Carter Van Waes and Zhong Chen*

Genome Biology 2007, 8:R78 doi:10.1186/gb-2007-8-5-r78

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A systems biology approach to the identification and analysis of transcriptional regulatory networks in osteocytes

Angela K Dean, Stephen E Harris, Ivo Kalajzic, Jianhua Ruan BMC Bioinformatics 2009, 10(Suppl 9):S5 (17 September 2009)

Abstract | Full text | PDF | PubMed

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Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status

Bin Yan, Guang Chen, Kunal Saigal, Xinping Yang, Shane T Jensen, Carter Van Waes, Christian J Stoeckert, Zhong Chen Genome Biology 2008, 9:R53 (11 March 2008)

Abstract | Full text | PDF | PubMed | Editor’s summary

Detailed analysis of NFκB regulons in 1,265 genes differentially expressed in head and neck cancer cell lines differing in p53 status revealed a cross talk between NFkB and specific signaling pathways.

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