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Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma

Bin Yan1 email, Xinping Yang1 email, Tin-Lap Lee2 email, Jay Friedman1 email, Jun Tang3 email, Carter Van Waes1 email and Zhong Chen1 email

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Center Drive, Bethesda, Maryland 20892, USA

Laboratory of Clinical Genomics, National Institute of Child Health and Human Development, National Institutes of Health, Convent Drive, Bethesda, MD 20892, USA

Department of Preventive Medicine, University of Tennessee, Health Science Center, N Pauline St., Memphis, TN 38163, USA

author email corresponding author email

Genome Biology 2007, 8:R78doi:10.1186/gb-2007-8-5-r78

Published: 11 May 2007

Subject areas: Cancer, Genome studies, Bioinformatics


Additional files

Additional data file 1:

Shown is a list of genes in cluster C (over-expressed in UM-SCC cells).

Format: PDF Size: 169KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional data file 2:

Included are GO annotations of genes in clusters A to C (over-expressed in UM-SCC cells) and of genes in clusters D to F (under-expressed in UM-SCC cells).

Format: PDF Size: 40KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional data file 3:

Provided are sequences, location, and matrix similarity of putative TFBSs in genes in clusters A and B (over-expressed in UM-SCC cells).

Format: PDF Size: 409KB Download file

This file can be viewed with: Adobe Acrobat Reader


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