Figure 2.

Upstream sequence conservation of protein coding versus miRNA genes. Comparison of 5-kilobase upstream sequence conservation between human and various organisms, relative to the transcription start site (TSS; protein-coding, solid blue line) and gene start (intergenic microRNA [miRNA] genes, orange line). The conservation of developmental genes (light blue dotted line) and tRNA genes (green dotted line) are also plotted for comparison purposes. For the plot 100 base pair (bp) intervals were used for the first 500 bp and 500 bp intervals thereafter.