Table 7 |
||||||
|
Human-opossum TFBS conservation dependency on the GO category of the downstream regulated gene |
||||||
|
GO category |
Number of genes |
Upstream Coverage |
Detectable TFBSs |
% TFBS Detected |
p value |
Over/under |
|
|
||||||
|
Receptor binding |
51 |
6.49% |
180 |
55.56% |
5.80 × 10-6 |
Over* |
|
Cell-cell signaling |
35 |
6.37% |
120 |
51.67% |
3.67 × 10-3 |
Over |
|
Physiologic process |
122 |
5.63% |
415 |
49.40% |
1.51 × 10-6 |
Over* |
|
Response to external stimulus |
54 |
5.60% |
168 |
48.81% |
6.12 × 10-3 |
Over |
|
Transcription regulator activity |
32 |
10.15% |
122 |
47.54% |
2.47 × 10-2 |
Over |
|
Extracellular space |
43 |
4.08% |
175 |
47.43% |
1.23 × 10-2 |
Over |
|
Response to biotic stimulus |
60 |
5.29% |
209 |
47.37% |
7.82 × 10-3 |
Over |
|
Transcription |
61 |
10.52% |
208 |
45.67% |
2.13 × 10-2 |
Over |
|
Transcription factor activity |
40 |
9.80% |
133 |
45.11% |
4.65 × 10-2 |
Over |
|
Development |
47 |
9.48% |
120 |
45.00% |
5.25 × 10-2 |
|
|
Signal transduction |
86 |
5.72% |
293 |
44.71% |
1.95 × 10-2 |
Over |
|
Response to stress |
74 |
6.23% |
268 |
44.03% |
3.18 × 10-2 |
Over |
|
Regulation of biologic process |
134 |
8.49% |
490 |
43.06% |
2.59 × 10-2 |
Over |
|
Cell |
82 |
6.11% |
241 |
40.66% |
5.96 × 10-2 |
|
|
Nucleus |
81 |
10.05% |
305 |
40.66% |
5.52 × 10-2 |
|
|
Extracellular region |
44 |
6.17% |
160 |
40.63% |
6.95 × 10-2 |
|
|
Cell proliferation |
49 |
7.63% |
196 |
40.31% |
6.26 × 10-2 |
|
|
Mitochondrion organization and biogenesis |
77 |
6.90% |
213 |
39.44% |
5.29 × 10-2 |
|
|
Cytoplasm |
34 |
6.07% |
97 |
39.18% |
7.95 × 10-2 |
|
|
Cell death |
41 |
6.77% |
164 |
37.80% |
4.34 × 10-2 |
Under |
|
Protein binding |
122 |
7.01% |
419 |
35.80% |
4.81 × 10-4 |
Under* |
|
Cell cycle |
39 |
7.67% |
176 |
35.23% |
1.35 × 10-2 |
Under |
|
Nucleotide binding |
32 |
5.82% |
112 |
31.25% |
5.81 × 10-3 |
Under |
|
Protein complex |
28 |
5.90% |
84 |
29.76% |
7.37 × 10-3 |
Under |
|
DNA binding |
27 |
10.05% |
74 |
29.73% |
1.08 × 10-2 |
Under |
|
Binding |
71 |
6.77% |
240 |
29.58% |
5.58 × 10-6 |
Under* |
|
Receptor activity |
31 |
6.53% |
88 |
29.55% |
5.67 × 10-3 |
Under |
|
Plasma membrane |
37 |
4.78% |
91 |
28.57% |
3.00 × 10-3 |
Under |
|
Protein metabolism |
41 |
6.27% |
131 |
25.95% |
3.75 × 10-5 |
Under* |
|
Transporter activity |
31 |
6.28% |
91 |
23.08% |
6.74 × 10-5 |
Under* |
|
Transport |
32 |
5.53% |
102 |
20.59% |
1.85 × 10-6 |
Under* |
|
|
||||||
|
See Table 6 footnote for details. |
||||||
|
Mahony et al. Genome Biology 2007 8:R84 doi:10.1186/gb-2007-8-5-r84 |
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