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A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database

José L Jiménez1*, Björn Hegemann2, James RA Hutchins2, Jan-Michael Peters2 and Richard Durbin1

Author affiliations

1 Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

2 Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, 1030 Vienna, Austria

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Citation and License

Genome Biology 2007, 8:R90  doi:10.1186/gb-2007-8-5-r90

Published: 23 May 2007

Abstract

mtcPTM is an online repository of human and mouse phosphosites in which data are hierarchically organized to preserve biologically relevant experimental information, thus allowing straightforward comparisons of phosphorylation patterns found under different conditions. The database also contains the largest available collection of atomic models of phosphorylatable proteins. Detailed analysis of this structural dataset reveals that phosphorylation sites are found in a heterogeneous range of structural and sequence contexts. mtcPTM is available on the web http://www.mitocheck.org/cgi-bin/mtcPTM/search webcite.