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Open Access Research

Gene expression variation in Down's syndrome mice allows prioritization of candidate genes

Marc Sultan1*, Ilaria Piccini1, Daniela Balzereit1, Ralf Herwig1, Nidhi G Saran2, Hans Lehrach1, Roger H Reeves23 and Marie-Laure Yaspo1

Author Affiliations

1 Max Planck Institute for Molecular Genetics, Ihnestr.63/73, 14195, Berlin, Germany

2 Department of Physiology, Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, Maryland 21205, USA

3 McKusick-Nathans Institute of Genetic Medicine, 733 Nth. Broadway, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

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Genome Biology 2007, 8:R91  doi:10.1186/gb-2007-8-5-r91

Published: 25 May 2007

Additional files

Additional data file 1:

Provided is a table listing the references of the gene expression assay (Applied Biosystems) that were used for quantitative RT-PCR experiments.

Format: PDF Size: 91KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 2:

Provided is a figure of the correlation plot of intensities from electronic pools (y-axis) versus biologic pools (x-axis) for each gene in the three brain tissues.

Format: TIFF Size: 4.9MB Download file

Open Data

Additional data file 3:

Provided is a summary table listing the following information for each gene and each brain tissue analyzed: gene names (triplicated genes in Ts65Dn are in red), mean expressions (ME) of Ts65Dn and euploid mice, standard errors of MEs, CVs of the Ts65Dn and euploid samples, technical and biologic variance, mean trisomic:euploid gene expression ratios from electronic and RNA pools, and P values from t-test, tu-test, Wilcoxon test, permutation test, and F-test.

Format: PDF Size: 187KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 4:

Provided is a scatter plot of CVs of euploid versus Ts65Dn mice in brain tissues. The dotted lines represent the ± 20% CV deviations from the ideal correlation (plain line).

Format: TIFF Size: 9.1MB Download file

Open Data