Research
Gene expression variation in Down's syndrome mice allows prioritization of candidate genes
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* Corresponding author: Marc Sultan sultan@molgen.mpg.de
1 Max Planck Institute for Molecular Genetics, Ihnestr.63/73, 14195, Berlin, Germany
2 Department of Physiology, Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, Maryland 21205, USA
3 McKusick-Nathans Institute of Genetic Medicine, 733 Nth. Broadway, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Genome Biology 2007, 8:R91 doi:10.1186/gb-2007-8-5-r91
Published: 25 May 2007Additional files
Additional data file 1:
Provided is a table listing the references of the gene expression assay (Applied Biosystems) that were used for quantitative RT-PCR experiments.
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Additional data file 2:
Provided is a figure of the correlation plot of intensities from electronic pools (y-axis) versus biologic pools (x-axis) for each gene in the three brain tissues.
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Additional data file 3:
Provided is a summary table listing the following information for each gene and each brain tissue analyzed: gene names (triplicated genes in Ts65Dn are in red), mean expressions (ME) of Ts65Dn and euploid mice, standard errors of MEs, CVs of the Ts65Dn and euploid samples, technical and biologic variance, mean trisomic:euploid gene expression ratios from electronic and RNA pools, and P values from t-test, tu-test, Wilcoxon test, permutation test, and F-test.
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Additional data file 4:
Provided is a scatter plot of CVs of euploid versus Ts65Dn mice in brain tissues. The dotted lines represent the ± 20% CV deviations from the ideal correlation (plain line).
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