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Open Access Highly Accessed Research

Unequal evolutionary conservation of human protein interactions in interologous networks

Kevin R Brown12 and Igor Jurisica123*

Author Affiliations

1 Department of Medical Biophysics, University of Toronto, Toronto, Canada M5G 1L7

2 Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Canada M5G 1L7

3 Department of Computer Science, University of Toronto, Toronto, Canada M5G 1L71

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Genome Biology 2007, 8:R95  doi:10.1186/gb-2007-8-5-r95

Published: 29 May 2007

Additional files

Additional data file 1:

PPI datasets that were compiled and used in this study, along with their sources.

Format: XLS Size: 24KB Download file

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Open Data

Additional data file 2:

Properties of the source and predicted protein interaction networks, including overlapping PPI, clustering coefficient (Cw), and average protein degree (<k>).

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Open Data

Additional data file 3:

High confidence subset of yeast PPI [28] data, integrated with gene expression data from Gasch et al. [29].

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Open Data

Additional data file 4:

Cumulative distributions of joint sequence identity [4] for PPI mapped from humans to the model organisms.

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Open Data

Additional data file 5:

Results of permutation testing on co-localization of protein pairs.

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Open Data

Additional data file 6:

Overlap between the yeast PPI network, and the predictions made from the human interactome.

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Additional data file 7:

Yeast PPI network constructed using predictions from human PPIs, illustrating the conservation of protein complexes.

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Open Data

Additional data file 8:

Results of filtering the BLAST data sources for redundant protein sequences.

Format: XLS Size: 27KB Download file

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Open Data