Research
Unequal evolutionary conservation of human protein interactions in interologous networks
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* Corresponding author: Igor Jurisica juris@ai.utoronto.ca
1 Department of Medical Biophysics, University of Toronto, Toronto, Canada M5G 1L7
2 Ontario Cancer Institute, Toronto Medical Discovery Tower, Toronto, Canada M5G 1L7
3 Department of Computer Science, University of Toronto, Toronto, Canada M5G 1L71
Genome Biology 2007, 8:R95 doi:10.1186/gb-2007-8-5-r95
Published: 29 May 2007Additional files
Additional data file 1:
PPI datasets that were compiled and used in this study, along with their sources.
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Additional data file 2:
Properties of the source and predicted protein interaction networks, including overlapping PPI, clustering coefficient (Cw), and average protein degree (<k>).
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Additional data file 3:
High confidence subset of yeast PPI [28] data, integrated with gene expression data from Gasch et al. [29].
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Additional data file 4:
Cumulative distributions of joint sequence identity [4] for PPI mapped from humans to the model organisms.
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Additional data file 5:
Results of permutation testing on co-localization of protein pairs.
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Additional data file 6:
Overlap between the yeast PPI network, and the predictions made from the human interactome.
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Additional data file 7:
Yeast PPI network constructed using predictions from human PPIs, illustrating the conservation of protein complexes.
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Additional data file 8:
Results of filtering the BLAST data sources for redundant protein sequences.
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