Table 3

Gene co-expression in known and predicted human PPI networks

Dataset

Mean correlation

n

Known human

0.241

5,201

Predicted, overlapping

0.408

242

Predicted, non-overlapping

0.412

4,571

Predicted, >1 org

0.717

115

Random

0.09

10,000

Gene expression analysis was performed on the human GeneAtlas [37]. 'Predicted, overlapping' are interactions predicted from model organisms, and also found in the known human dataset. 'Predicted, non-overlapping' are novel predictions not found in the known human interaction databases. 'Predicted, >1 org' are PPIs inferred from more than one model organism, regardless of overlap with the known human PPI network.

Brown and Jurisica Genome Biology 2007 8:R95   doi:10.1186/gb-2007-8-5-r95