Research
Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains
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* Corresponding author: Laurence Rohmer lrohmer@u.washington.edu
1 Department of Genome Sciences, University of Washington, Campus Box 357710, 1705 NE Pacific street Seattle, Washington 98195, USA
2 Department of Pediatrics, Division of Infectious Diseases, University of Washington, Campus Box 357710, 1720 NE Pacific street, Seattle, Washington 98195, USA
3 NBC Analysis, Division of NBC Defence, Swedish Defence Research Agency, SE-901 82 Umeå, Sweden
4 Department of Clinical Microbiology, Infectious Diseases, Umeå University, SE-901 85 Umeå, Sweden
5 University of Washington Genome Center, University of Washington, Campus Box 352145, Mason Road, Seattle, Washington 98195, USA
6 Department Medicine, University of Washington, Seattle, Washington 98195, USA
7 Department of Microbiology, University of Washington, Box 357242, 1720 NE Pacific street, Seattle, Washington 98195, USA
8 Department of Medicinal Chemistry, Box 357610, University of Washington, Seattle, Washington 98195, USA
Genome Biology 2007, 8:R102 doi:10.1186/gb-2007-8-6-r102
Published: 5 June 2007Additional files
Additional data file 1:
A total of 1,745 genes (functional or inactivated) were identified in Francisella tularensis subspecies novicida U112; its orthologous counterpart in the genome of Francisella tularensis subspecies tularensis Schu S4 and Francisella tularensis subspecies holarctica LVS is listed when available.
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Additional data file 2:
Eighty candidate virulence genes of Francisella tularensis subspecies novicida U112 are also present in holarctica and tularensis genomes.
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Additional data file 3:
Provided is a list of the duplicated genes (100% identity) in the genomes of Francisella tularensis subspecies tularensis Schu S4 and Francisella tularensis subspecies holarctica LVS, and their counterpart in Francisella tularensis subspecies novicida U112.
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