Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains

Laurence Rohmer¹ , Christine Fong¹ , Simone Abmayr¹ , Michael Wasnick¹ , Theodore J Larson Freeman¹ , Matthew Radey¹ , Tina Guina² , Kerstin Svensson^3,4 , Hillary S Hayden⁵ , Michael Jacobs⁵ , Larry A Gallagher¹ , Colin Manoil¹ , Robert K Ernst⁶ , Becky Drees⁷ , Danielle Buckley⁵ , Eric Haugen⁵ , Donald Bovee⁵ , Yang Zhou⁵ , Jean Chang⁵ , Ruth Levy⁵ , Regina Lim⁵ , Will Gillett⁵ , Don Guenthener⁵ , Allison Kang⁵ , Scott A Shaffer⁸ , Greg Taylor⁸ , Jinzhi Chen⁸ , Byron Gallis⁸ , David A D'Argenio⁷ , Mats Forsman³ , Maynard V Olson^1,5,6 , David R Goodlett⁸ , Rajinder Kaul^5,6 , Samuel I Miller^1,6,7 and Mitchell J Brittnacher¹

¹Department of Genome Sciences, University of Washington, Campus Box 357710, 1705 NE Pacific street Seattle, Washington 98195, USA

²Department of Pediatrics, Division of Infectious Diseases, University of Washington, Campus Box 357710, 1720 NE Pacific street, Seattle, Washington 98195, USA

³NBC Analysis, Division of NBC Defence, Swedish Defence Research Agency, SE-901 82 Umeå, Sweden

⁴Department of Clinical Microbiology, Infectious Diseases, Umeå University, SE-901 85 Umeå, Sweden

⁵University of Washington Genome Center, University of Washington, Campus Box 352145, Mason Road, Seattle, Washington 98195, USA

⁶Department Medicine, University of Washington, Seattle, Washington 98195, USA

⁷Department of Microbiology, University of Washington, Box 357242, 1720 NE Pacific street, Seattle, Washington 98195, USA

⁸Department of Medicinal Chemistry, Box 357610, University of Washington, Seattle, Washington 98195, USA