Additional data file 7.

A figure showing a network map of the NFκB modulators. An adjacency matrix was constructed on the basis of the orientation flags from the dominant-negative and constitutively active screens (that is, upstream, downstream, or unclassified). The adjacency matrix containing the experimental data was merged with a separate adjacency matrix containing members of the currently accepted NFκB signaling network. Based on the combined adjacency matrix, a network map was constructed as a rooted tree with the NFκB complex serving as the obligate root node. The longest path was calculated from each terminal node to the root node. Peach nodes = positive modulators; green nodes = negative modulators; pink nodes = genes identified as both positive and negative modulators; orange nodes = members of the known NFκB signaling network; red nodes = dominant-negative mutants (plus TRAF2); blue nodes = positive modulators whose network location was adjusted based on the currently accepted NFκB network structure.

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Halsey et al. Genome Biology 2007 8:R104   doi:10.1186/gb-2007-8-6-r104